Recruiting

Create Wellness vs. Creatine Monohydrate

Sponsor:

University of Oklahoma

Code:

NCT07579455

Conditions

Creatine Absorption in Healthy Adults

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Interventions

Create Wellness Creatine Gummies

Creatine Monohydrate Powder

Study Details

Brief summary:

The purpose of this study is to compare blood creatine levels following acute oral supplementation of Create Wellness creatine gummies to creatine monohydrate powder.

Conditions

Creatine Absorption in Healthy Adults

Study ID

NCT07579455

Start date

Jun, 2026

Status verified date

May, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adults between the ages of 18-45 yrs
  • Body mass index of <35 kg/m2
  • Recreationally active \[(≥30 minutes of moderate-intensity physical activity per week as defined by the International Physical Activity Questionnaire (IPAQ)\]
  • Healthy and free from major diseases as determined from screening call and health history questionnaire.
  • Agrees to complete pre-assessment guidelines (8-hour fast from caloric foods and beverages, 24-hour abstention from vigorous physical activity, caffeine, alcohol, and tobacco).

Exclusion Criteria:

  • Chronic kidney disease, liver disease, chronic obstructive pulmonary disease, or cancer.
  • Currently using medications that may directly impact the primary outcomes including: diuretics and corticosteroids).
  • Currently using creatine monohydrate
  • Severely impaired hearing or speech or inability to speak English.

Study Design

Enrollment

16 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Sequence A (Gummy, Powder)

experimental: Sequence B (Powder, Gummy)

Interventions

Create Wellness Creatine Gummies

Create Wellness creatine gummies provide 4.5 grams of creatine monohydrate in a 3 gummy serving size.

Creatine Monohydrate Powder

4.5 grams of creatine monohydrate powder (Creapure®) dissolved in 240 mL of water.

Primary outcome measure

  • Peak plasma concentration (Cmax) [ Time Frame: 0 to 5-hours following supplementation. ]
  • Time to peak plasma concentration (Tmax) [ Time Frame: 0 to 5-hours following supplementation. ]
  • Area under the curve (AUC) [ Time Frame: 0 to 5-hours following supplementation. ]

Central Contacts and Locations

Central contacts

Sam R. Moore, PhD

4053252542samray@ou.edu

Locations

ATHENA Laboratory

Recruiting

Norman, Oklahoma, United States, 73019

Contacts

Sam R. Moore, PhD

405-325-2542samray@ou.edu

More Information

Sponsor

University of Oklahoma

Last update posted

May 28, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Oklahoma on 2026-05-28.