Recruiting

OpenCap

Sponsor:

VA Office of Research and Development

Code:

NCT07580222

Conditions

Osteoarthritis, Knee

Eligibility Criteria

Sex: All

Age: 30+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Veterans face a high prevalence of knee osteoarthritis (OA), but current diagnostic methods often miss early stages when interventions are more effective. This project will evaluate smartphone-based motion capture via OpenCap to measure joint mechanics in knee OA patients during functional activities, comparing its performance to a conventional motion capture system, patient-reported symptoms, and knee joint structure. The findings will have the potential to enable clinicians to trial OpenCap in its current form, provide insights into tracking joint health, and guide refinements to advance toward earlier diagnosis of knee OA by complementing symptom assessments with measures of joint mechanics.

Conditions

Osteoarthritis, Knee

Study ID

NCT07580222

Start date

Apr 1, 2026

Status verified date

May, 2026

Completion date

Mar 31, 2028

Anticipated

Primary completion date

Sep 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 30+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Veteran and non-Veterans
  • males and females
  • diagnosed with early knee osteoarthritis
  • qualified for and participated in the Precision Assessment of Platelet Rich Plasma for Joint Preservation study (ClinicalTrials.gov ID: NCT03460236)
  • able and willing to provide informed consent for follow-up study

Exclusion Criteria:

  • symptomatic OA in joints other than the knee in the lower body
  • joint replacement
  • rheumatic disease
  • BMI > 35 kg/m\^2
  • severe systematic disease defined as American Society of Anesthesiologists (ASA) 3 or above
  • pregnant or intending to become pregnant during the study

Study Design

Enrollment

47 participants

Anticipated

Interventions and Outcome Measures

Arms

Knee OA

Adults who were previously diagnosed with early knee osteoarthritis, enrolled in Precision Assessment of Platelet Rich Plasma for Joint Preservation study (NCT03460236), and able and willing to participate in the follow-up assessment.

Primary outcome measure

  • Knee flexion angle [ Time Frame: Baseline and Week 1 ]

Central Contacts and Locations

Central contacts

Jade He, PhD

(650) 493-5000Jade.He@va.gov

Locations

VA Palo Alto Health Care System, Palo Alto, CA

Recruiting

Palo Alto, California, United States, 94304-1207

Contacts

Jade He, PhD

650-493-5000Jade.He@va.gov

Principal Investigator:

Jade He, PhD

More Information

Sponsor

VA Office of Research and Development

Last update posted

May 12, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by VA Office of Research and Development on 2026-05-12.