Recruiting

Low Energy Availability

Sponsor:

North Carolina Agriculture & Technical State University

Code:

NCT07583940

Conditions

Vascular Stiffness

Hypertension (HTN)

Nutritional Deficiency Related Cardiovascular Risk in Athletes

Eligibility Criteria

Sex: All

Age: 18 - 26

Healthy Volunteers: Accepted

Study Details

Brief summary:

Low energy availability (LEA) occurs when the body does not get enough calories to support both daily life and exercise. This can happen when athletes train hard but do not eat enough to match their energy needs. In both 2012 and 2023, the International Olympic Committee on Sports Nutrition recognized LEA as an important factor that can increase the risk of cardiometabolic disease (CMD), which includes conditions like high blood pressure, diabetes, and heart disease. LEA can affect many systems in the body. It may disrupt hormones (such as menstrual cycles), cause changes in blood sugar and cholesterol levels, weaken bones, impair digestion, and negatively impact mental health. Over time, these changes may be linked to chronic inflammation, which plays a key role in the development of disease. Maintaining proper energy balance can be especially challenging for athletes because they often train at levels well above general health recommendations. As a result, even highly fit athletes may unintentionally remain in a calorie deficit. Our recent pilot research found a significant relationship between LEA and high blood pressure in Black Division I collegiate athletes. This is important because this group has historically been understudied and may face a higher risk of serious heart-related events, including sudden cardiac death. Despite assumptions that collegiate athletes are uniformly healthy, there is a need to better understand hidden health risks in this population. Our research aims to improve how we identify and monitor early signs of cardiometabolic disease by examining markers such as inflammation, blood sugar, and cholesterol levels. These insights will help healthcare providers, athletes, and families make more informed decisions about nutrition, training, and long-term health. Ultimately, this work seeks to develop practical, evidence-based strategies to protect athlete health and reduce the risk of serious cardiovascular outcomes.

Conditions

Vascular Stiffness

Hypertension (HTN)

Nutritional Deficiency Related Cardiovascular Risk in Athletes

Study ID

NCT07583940

Start date

Jan 6, 2026

Status verified date

May, 2026

Completion date

Jun 30, 2028

Anticipated

Primary completion date

May 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 26

Healthy Volunteers: Accepted

Inclusion Criteria:

Age: 18-25yrs Sex: Male and Female Training Status/Experience: HBCU Division I collegiate athletes with >3yrs of previous competitive experience

Exclusion Criteria:

  • Persons who self-report any known disease, or unknown issue precluding collegiate competitive participation: Excluded
  • Those who have any orthopedic injuries, concussions, or conditions which would preclude safe testing: Excluded
  • Individuals who are not yet adults <18yrs (e.g.: infants, children, teenagers):

Excluded

  • Persons who have a pacemaker: Excluded
  • Persons who are pregnant: Excluded

Study Design

Enrollment

150 participants

Anticipated

Interventions and Outcome Measures

Arms

Division I HBCU Athletes

Division I athletes with a minimum of >3yrs experience tested once inside the competitive season and once outside of the competitive season beginning January 2026.

Primary outcome measure

  • Pulse wave velocity (PWV) [ Time Frame: Enrollment to the second time point will not exceed 26 weeks. Testing once within the competitive season and once outside the competitive season (off season). ]
  • Energy availability [ Time Frame: Enrollment to the second time point will not exceed 26 weeks. Testing once within the competitive season and once outside the competitive season (off season). ]

Central Contacts and Locations

Central contacts

Catherine Bush, PhD

3363347712cmbush@ncat.edu

Locations

North Carolina Agricultural & Technical State University

Recruiting

Greensboro, North Carolina, United States, 27411

Contacts

Troy M Purdom, PhD

3362853552tpurdom@ncat.edu

Catherine Bush, PhD, MPH

336-334-7712cmbush@ncat.edu

More Information

Sponsor

North Carolina Agriculture & Technical State University

Last update posted

May 13, 2026

Last verified

May, 2026

Keywords

  • vascular stiffness,
  • hypertension
  • nutritional deficiency
  • energy balance
  • RED-S
  • SDOH

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by North Carolina Agriculture & Technical State University on 2026-05-13.