Recruiting

aTSA vs. rTSA

Sponsor:

Mayo Clinic

Code:

NCT07584356

Conditions

Shoulder Arthritis

Eligibility Criteria

Sex: All

Age: 60 - 70+

Healthy Volunteers: Not accepted

Interventions

aTSA

rTSA

Study Details

Brief summary:

The purpose of this study is to determine if patients undergoing anatomic total shoulder arthroplasty (aTSA) will have improved patient reported outcome scores at 1 year compared to those undergoing reverse total shoulder arthroplasty (rTSA).

Conditions

Shoulder Arthritis

Study ID

NCT07584356

Start date

May 5, 2026

Status verified date

Aug, 2026

Completion date

Dec, 2029

Anticipated

Primary completion date

Jul, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 60 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria

  • Shoulder arthritis
  • Intact rotator cuff
  • Glenoid retroversion less than 25°

Exclusion Criteria

  • Rotator cuff insufficiency
  • Fracture deformity/sequelae
  • Severe glenoid deformity (C glenoid, severe A2, B2 glenoid)
  • Current or previous infection of shoulder
  • Previous acromion fracture (not os acromiale)
  • Brachial plexopathy
  • Axillary neuropathy
  • Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.
  • Inability or unwillingness of individual or legal guardian/representative to give written informed consent.
  • Medical conditions that would make 2 years follow up unlikely
  • Non-English speaking

Study Design

Enrollment

108 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

other: Anatomic total shoulder arthroplasty (aTSA)

other: Reverse total shoulder arthroplasty (rTSA)

Interventions

aTSA

Patients with shoulder arthritis with an intact rotator cuff that requires surgical correction will undergo anatomic total shoulder arthroplasty (aTSA) procedure.

rTSA

Patients with shoulder arthritis with an intact rotator cuff that requires surgical correction will undergo reverse total shoulder arthroplasty (rTSA) procedure.

Primary outcome measure

  • American Shoulder and Elbow Surgeons (ASES) Questionnaire score [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Lucille I Anderson, CCRP

507-538-5627anderson.luci@mayo.edu

Xavier C Gendry

507-266-0687gendry.xavier@mayo.edu

Locations

Mayo Clinic in Rochester

Recruiting

Rochester, Minnesota, United States, 55905

Contacts

Lucille I Anderson, CCRP

507-538-5627anderson.luci@mayo.edu

Principal Investigator:

Jonathan D. Barlow, MD

More Information

Sponsor

Mayo Clinic

Last update posted

Aug 19, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-08-19.