Recruiting

Predictive Model

Sponsor:

City of Hope Medical Center

Code:

NCT07587229

Conditions

Gastric Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Observational study (no intervention)

Study Details

Brief summary:

This study aims to develop a model to predict response to chemotherapy in gastric cancer using RNA splicing information from tumor tissue.

By analyzing genetic patterns and applying machine learning, the study seeks to identify patients who are less likely to benefit from treatment, helping guide clinical decision-making.

Conditions

Gastric Cancer

Study ID

NCT07587229

Start date

May 1, 2026

Status verified date

May, 2026

Completion date

Jan 1, 2027

Anticipated

Primary completion date

Jan 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Pathologically confirmed stage II or III gastric cancer
  • Underwent curative surgical resection
  • Received 5-FU-based adjuvant chemotherapy
  • Availability of tumor tissue samples for analysis

Exclusion Criteria:

  • History of other malignancies
  • Inadequate or poor-quality tissue samples (e.g., contamination)

Study Design

Enrollment

329 participants

Anticipated

Interventions and Outcome Measures

Arms

Responder

Patients with stage II/III gastric cancer who did not develop recurrence within 3 years after curative surgery following adjuvant chemotherapy.

Non-responder

Patients with stage II/III gastric cancer who developed recurrence within 3 years after curative surgery following adjuvant chemotherapy.

Interventions

Observational study (no intervention)

This is an observational study without assigned interventions. All patients received standard-of-care 5-FU-based adjuvant chemotherapy, and no experimental intervention was performed.

Primary outcome measure

  • Treatment response based on 3-year recurrence-free survival [ Time Frame: 3 years after surgery ]

Central Contacts and Locations

Central contacts

Ajay Goel

626-256-4673ajgoel@coh.org

Locations

City of Hope Medical Center

Recruiting

Duarte, California, United States, 91016

More Information

Sponsor

City of Hope Medical Center

Last update posted

May 14, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by City of Hope Medical Center on 2026-05-14.