Recruiting

Phase 2

Macupatide & EloralintideA Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Sponsor:

Eli Lilly and Company

Code:

NCT07589608

Conditions

Overweight

Obesity

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Macupatide

Eloralintide

Placebo

Study Details

Brief summary:

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.

Conditions

Overweight

Obesity

Study ID

NCT07589608

Start date

May 15, 2026

Status verified date

Oct, 2026

Completion date

Feb, 2028

Anticipated

Primary completion date

Sep, 2027

Anticipated

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

See Master Protocol CWMM (NCT06143956) for inclusion criteria

Exclusion Criteria:

In addition to exclusion criteria in Master Protocol CWMM (NCT06143956):

Have type 1 diabetes or type 2 diabetes
Have an ongoing history of bradyarrhythmia and/or sinus bradycardia
Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm)
Have a history of acute or chronic pancreatitis
All concomitant medications should be at a stable dose for at least 3 months prior to screening

Study Design

Enrollment

400 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Macupatide Dose 1

Participants will receive macupatide subcutaneously (SC)

experimental: Eloralintide Dose 1

Participants will receive eloralintide SC

experimental: Macupatide Dose 1 + Eloralintide Dose 1

Participants will receive macupatide SC and eloralintide SC

experimental: Eloralintide Dose 2

Participants will receive eloralintide SC

experimental: Macupatide Dose 1 + Eloralintide Dose 2

Participants will receive macupatide SC and eloralintide SC

experimental: Eloralintide Dose 3

Participants will receive eloralintide SC

experimental: Macupatide Dose 2 + Eloralintide Dose 3

Participants will receive macupatide SC and eloralintide SC

placebo comparator: Placebo

Participants will receive placebo SC

Interventions

Macupatide

Administered SC

Eloralintide

Administered SC

Placebo

Administered SC

Primary outcome measure

Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 36 ]

Central Contacts and Locations

Central contacts

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

317-615-4559 LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact

clinical_inquiry_hub@lilly.com

Locations

The Institute for Liver Health II dba Arizona Clinical Trials - Mesa

Recruiting

Chandler, Arizona, United States, 85225

Principal Investigator:

Yessica Sachdeva

Headlands Research - Scottsdale

Recruiting

Scottsdale, Arizona, United States, 85260

Principal Investigator:

Benjamin Clark

The Institute for Liver Health II dba Arizona Liver Health-Tucson

Recruiting

Tucson, Arizona, United States, 85712

Principal Investigator:

Anita Kohli

NorCal Medical Research, Inc

Recruiting

Greenbrae, California, United States, 94904

Principal Investigator:

Linda Gaudiani

Velocity Clinical Research, Huntington Park

Recruiting

Huntington Park, California, United States, 90255

Principal Investigator:

Stanley Hsia

Peninsula Research Associates

Recruiting

Rolling Hills Estates, California, United States, 90274

Principal Investigator:

LeighAnn Schmidt

Diablo Clinical Research, Inc.

Recruiting

Walnut Creek, California, United States, 94598

Principal Investigator:

Bonnie Kimmel

Stamford Therapeutics Consortium

Recruiting

Stamford, Connecticut, United States, 06905

Principal Investigator:

David Radin

New Horizon Research Center

Recruiting

Miami, Florida, United States, 33165

Principal Investigator:

Lazaro Nunez

Indago Research & Health Center, Inc

Recruiting

Miami Lakes, Florida, United States, 33016

Principal Investigator:

Jose Cardona

Suncoast Clinical Research, Inc.

Recruiting

New Port Richey, Florida, United States, 34652

Principal Investigator:

Cathy Barnes

Charter Research - Winter Park

Recruiting

Orlando, Florida, United States, 32803

Principal Investigator:

Edgardo Rivera-Rivera

Charter Research - Lady Lake

Recruiting

The Villages, Florida, United States, 32162

Principal Investigator:

Jeffrey Norton

Medical Research Partners

Recruiting

Ammon, Idaho, United States, 83406

Principal Investigator:

Joseph Moore

Great Lakes Clinical Trials - Ravenswood

Recruiting

Chicago, Illinois, United States, 60640

Principal Investigator:

Rupal Trivedi

Cotton O'Neil Diabetes & Endocrinology

Recruiting

Topeka, Kansas, United States, 66606

Principal Investigator:

susan brian

Monroe Biomedical Research - Louisville

Recruiting

Louisville, Kentucky, United States, 40213

Principal Investigator:

Harold Bays

Knownwell

Recruiting

Needham, Massachusetts, United States, 02492

Principal Investigator:

Angela Fitch

Lucida Clinical Trials

Recruiting

New Bedford, Massachusetts, United States, 02740

Principal Investigator:

David Shih

Headlands Research - Detroit

Recruiting

Southfield, Michigan, United States, 48034

Principal Investigator:

Christopher Romero

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Recruiting

Troy, Michigan, United States, 48098

Principal Investigator:

Neil Fraser

StudyMetrix Research

Recruiting

City of Saint Peters, Missouri, United States, 63303

Principal Investigator:

Timothy Smith

Clinvest Headlands Llc

Recruiting

Springfield, Missouri, United States, 65807

Principal Investigator:

Christina Capps

Las Vegas Medical Research

Recruiting

Las Vegas, Nevada, United States, 89128

Principal Investigator:

Cornell Calinescu

Dent Neurologic Institute

Recruiting

Amherst, New York, United States, 14226

Principal Investigator:

Laszlo Mechtler

Rochester Clinical Research, LLC

Recruiting

Rochester, New York, United States, 14609

Principal Investigator:

Patrick Connors

Medication Management

Recruiting

Greensboro, North Carolina, United States, 27401

Principal Investigator:

James Franklin

Monroe Biomedical Research

Recruiting

Monroe, North Carolina, United States, 28112

Principal Investigator:

Awawu Igbinadolor

Lucas Research, Inc

Recruiting

Morehead City, North Carolina, United States, 28557

Principal Investigator:

Kathryn Lucas

Lucas Research, Inc.

Recruiting

New Bern, North Carolina, United States, 28562

Principal Investigator:

Joseph Maides

CTI Clinical Research Center

Recruiting

Cincinnati, Ohio, United States, 45212

Principal Investigator:

James Maynard

Tribe Clinical Research, LLC

Recruiting

Greenville, South Carolina, United States, 29607

Principal Investigator:

Ronald Mayfield

Quality Medical Research

Recruiting

Nashville, Tennessee, United States, 37211

Principal Investigator:

Saras Sharma

IMA Clinical Research Austin

Recruiting

Austin, Texas, United States, 78745

Principal Investigator:

Nomita Kim

FutureSearch Trials of Dallas

Recruiting

Dallas, Texas, United States, 75251

Principal Investigator:

Michael Downing

PlanIt Research, PLLC

Recruiting

Houston, Texas, United States, 77079

Principal Investigator:

Amer Al-Karadsheh

Endeavor Clinical Trials

Recruiting

San Antonio, Texas, United States, 78240

Principal Investigator:

Nitendra Agarwal

Texas Valley Clinical Research

Recruiting

Weslaco, Texas, United States, 78596

Principal Investigator:

Eduardo Luna

Sovah Clinical Research-River District

Recruiting

Danville, Virginia, United States, 24541

Principal Investigator:

Stephan Jannach

Central Washington Health Services Association d/b/a Confluence Health

Recruiting

Wenatchee, Washington, United States, 98801

Principal Investigator:

Kathryn Eren

More Information

Sponsor

Eli Lilly and Company

Last update posted

Oct 8, 2026

Last verified

Oct, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-17. This information was provided to ClinicalTrials.gov by Eli Lilly and Company on 2026-10-08. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.