Recruiting
Early Phase 1

Movement Feedback

Sponsor:

The Catholic University of America

Code:

NCT07598695

Conditions

Stroke

Eligibility Criteria

Sex: All

Age: 20 - 70

Healthy Volunteers: Accepted

Interventions

Visual ROM augmentation

Visual ROM reduction

Study Details

Brief summary:

The following experiment will be conducted with 15 chronic stroke survivors and 15 control subjects. Subjects will perform hand movements in the virtual reality environment using a head-mounted display. Quest's onboard cameras allow real-time tracking of hand motion, estimating joint angles of the finger and the thumb. For each feedback manipulation condition (i.e., movement amplification or reduction), the estimated joint angles will be multiplied by a factor greater than 1 (amplification) or a factor smaller than 1 (reduction). Then the newly-estimated hand posture will be displayed in the VR environment. Subjects will be randomly assigned into two groups (A and B), who will receive the assistance in a different order. Subjects will perform finger extension under three conditions: no sensory modulation, movement visual feedback (VF) amplification, and movement VF reduction (error augmentation), while their movement muscle activation patterns are recorded.

Conditions

Stroke

Study ID

NCT07598695

Start date

Oct 1, 2025

Status verified date

May, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Oct 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 20 - 70

Healthy Volunteers: Accepted

Inclusion Criteria for stroke group:

  • Age: 20 - 70 years old
  • First-ever unilateral cortical stroke with resultant hemiparesis at least 6 months prior to the experimental testing
  • Fugl-Meyer Upper Extremity Section 31 - 55

Exclusion Criteria for both groups:

  • Presence of concurrent severe medical illness
  • Pain in hand or arm with movements
  • Loss of voluntary control of fingers and thumb
  • Inability to provide informed consent
  • Musculoskeletal injuries (e.g., fracture) or medical complications (e.g., severe cardiovascular disease).

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Visual ROM augmentation followed by visual ROM reduction

experimental: Visual ROM reduction followed by visual ROM augmentation

Interventions

Visual ROM augmentation

Finger joint ROM is amplified.

Visual ROM reduction

Visual feedback of finger joint ROM is reduced.

Primary outcome measure

  • Joint range of motion (ROM) [ Time Frame: Periprocedural ]

Central Contacts and Locations

Central contacts

Sang Wook Lee, PhD

202-319-6218leesw@cua.edu

Locations

Catholic University of America

Recruiting

Washington D.C., District of Columbia, United States, 20064

Contacts

Sang Wook Lee, PhD

312-608-8001leesw@cua.edu

More Information

Sponsor

The Catholic University of America

Last update posted

May 22, 2026

Last verified

May, 2026

Keywords

  • Stroke
  • Muscle coordination
  • Visual feedback
  • Hand

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-11. This information was provided to ClinicalTrials.gov by The Catholic University of America on 2026-05-22.