Recruiting

Speech Amplification

Sponsor:

Michigan State University

Code:

NCT07599696

Conditions

Parkinson Disease

Atypical Parkinsonism

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Interventions

Behavioral speech strategies + speech amplification

Study Details

Brief summary:

The proposed research aims to investigate the use of speech amplification devices as a potential treatment option for people with Parkinson's disease and related disorders who exhibit hypophonia, a voice disorder that affects over half of those with Parkinson's disease. By characterizing the acoustic and perceptual effects of speech amplification and identifying ways to optimize outcomes through talker- and device-specific enhancements, this project seeks to develop personalized, evidence-based treatment options for hypophonia. The current proposal will move this effort forward by systematically eliciting and modifying speech amplification device output that leverage both behavioral and technological approaches.

Conditions

Parkinson Disease

Atypical Parkinsonism

Study ID

NCT07599696

Start date

Mar 1, 2024

Status verified date

May, 2026

Completion date

May 31, 2028

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Dominant speakers of North American English
  • Have received a neurologist's diagnosis of Parkinson disease or parkinsonism (e.g., PSP/MSA/PSP)
  • Present with changes in their speech/voice

Exclusion Criteria:

  • History of any other speech, language, or neurological concern other than Parkinson/parkinsonism.
  • Uncorrected hearing loss that exceeds a threshold of 40 dB HL in more than one ear (as per baseline screening audiometry) and/or use of a cochlear implant.

Study Design

Enrollment

100 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Speech Study

Single arm study: All speech conditions are administered.

Interventions

Behavioral speech strategies + speech amplification

Behavioral speech strategies + speech amplification

Primary outcome measure

  • Speech intensity [ Time Frame: Day 1 ]
  • Voice quality [ Time Frame: Day 1 ]
  • Articulation [ Time Frame: Day 1 ]

Central Contacts and Locations

Central contacts

Thea Knowles, PhD

517-353-6401thea@msu.edu

Locations

Michigan State University

Recruiting

East Lansing, Michigan, United States, 48823

Contacts

Thea Knowles, PhD

517-353-6401thea@msu.edu

Principal Investigator:

Thea Knowles, PhD

More Information

Sponsor

Michigan State University

Last update posted

May 20, 2026

Last verified

May, 2026

Keywords

  • speech
  • Parkinson's disease
  • atypical parkinsonism
  • speech acoustics
  • speech-language pathology
  • hypophonia
  • voice
  • voice disorders
  • speech disorders
  • dysarthria

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Michigan State University on 2026-05-20.