Recruiting

Sybil

Sponsor:

Massachusetts General Hospital

Code:

NCT07600801

Conditions

Family History of Lung Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

CT scan

Sybil

Study Details

Brief summary:

This research is being done to determine if an image-based deep learning model (Sybil) can accurately predict the likelihood of future lung cancer based on chest computed tomography (CT) imaging from individuals with a family history of lung cancer.

Conditions

Family History of Lung Cancer

Study ID

NCT07600801

Start date

Jun 17, 2026

Status verified date

Aug, 2026

Completion date

Dec 31, 2035

Anticipated

Primary completion date

Dec 31, 2033

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • ≥18 years of age
  • Positive family history of lung cancer (defined as):

  • Has ≥1 first-degree relative OR
  • Has ≥2 second-degree relatives with a diagnosis of non-small cell lung cancer or small cell lung cancer (NB: a first-degree relative = parent, sibling, or child, a second-degree relative = grandparent, blood-related aunt or uncle, grandchild, blood-related niece or nephew, half-sibling)
  • Willing to provide images from at least one previously obtained CT Chest scan, if available.

Exclusion Criteria:

\- None

Study Design

Enrollment

2250 participants

Anticipated

Interventions and Outcome Measures

Arms

Retrospective CT scan

Participants will contribute images and corresponding radiology reports from at least one retrospective CT chest scan.

Interventions

CT scan

Previously obtained computed tomography scan

Sybil

Image-based deep learning model

Primary outcome measure

  • Sybil's performance in predicting future lung cancer diagnoses [ Time Frame: From date of receival of retrospective CT scan for up to 2 years. ]

Central Contacts and Locations

Central contacts

Allison Chang, MD

617-724-4000aechang@mgb.org

Locations

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Allison Chang, MD

617-724-4000aechang@mgb.org

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Aug 25, 2026

Last verified

Aug, 2026

Keywords

  • Screening
  • CT Scan Images
  • Lung Cancer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2026-08-25.