Recruiting

Exercise Training

Sponsor:

The University of Texas Health Science Center, Houston

Code:

NCT07606742

Conditions

Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Exercise Training

Study Details

Brief summary:

The purpose of this study is to establish differences in the primary outcome of walking dysfunction using the 12-Item Multiple Sclerosis Walking Scale (MSWS-12) and to establish differences in the secondary outcome of HRQoL using the 29-Item Multiple Sclerosis Walking Scale (MSWS-29) between the exercise training intervention condition and the waitlist control condition following the 16-week intervention period.

Conditions

Multiple Sclerosis

Study ID

NCT07606742

Start date

Sep 1, 2026

Status verified date

Aug, 2026

Completion date

Oct 31, 2028

Anticipated

Primary completion date

Jun 30, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • diagnosis of MS
  • relapse-free in the past 30 days
  • self-identify as Hispanic/Latino
  • Patient Determined Disease Steps Scale (PDDS) score between 3.0 (gait disability) and 6.0 (bilateral support) indicates walking disability.
  • MSWS-12 score between 25 and 75, indicating walking disability
  • Willingness to complete the questionnaires and undergo randomization
  • English or Spanish as a primary language

Exclusion Criteria:

  • significant exercise-related risk factors or contraindications, assessed individually using the Physical Activity Readiness Questionnaire (PAR-Q; requires clearance from physician).

Study Design

Enrollment

66 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Exercise Training

no intervention: Waitlist Control

Interventions

Exercise Training

Participants will then be mailed exercise materials in their preferred language, including the program manual, logbook, calendar, newsletters, Fitbit, and resistance bands, along with instructions for telephone or video conference calls. This is a 16-week, home-based program, supported remotely via Internet-based behavioral coaching, which integrates behavior change techniques based on Social Cognitive Theory (SCT)

Primary outcome measure

  • Change in walking ability as assessed by the 12-Item Multiple Sclerosis Walking Scale (MSWS-12) [ Time Frame: Baseline, 16 weeks, 32 weeks ]

Central Contacts and Locations

Central contacts

Stephanie L Silveira, PhD

(713) 500-9490Stephanie.L.Silveira@uth.tmc.edu

Najha Black

713-500-9154Najha.C.Marshall@uth.tmc.edu

Locations

The University of Texas Health Science Center at Houston

Recruiting

Houston, Texas, United States, 77030

Contacts

Stephanie L Silveira, PhD

(713) 500-9000Stephanie.L.Silveira@uth.tmc.edu

Najha Black

713-500-9154Najha.C.Marshall@uth.tmc.edu

More Information

Sponsor

The University of Texas Health Science Center, Houston

Last update posted

Aug 6, 2026

Last verified

Aug, 2026

Keywords

  • Exercise training
  • mobility disability
  • implementation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by The University of Texas Health Science Center, Houston on 2026-08-06.