Recruiting

Ocrelizumab & rHuPH20

Sponsor:

Genentech, Inc.

Code:

NCT07609719

Conditions

Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Interventions

OCR SC

Study Details

Brief summary:

The purpose of this study is to assess the imaging biomarkers, patient outcomes, safety, tolerability, and treatment satisfaction of ocrelizumab (OCR) combined with recombinant human hyaluronidase (rHuPH20) administered subcutaneously (SC) in participants with relapsing multiple sclerosis (RMS) or primary progressive multiple sclerosis (PPMS) after switching from another anti-cluster of differentiation 20 (aCD20) therapy approved for RMS (ofatumumab SC, ublituximab-xiiy intravenous \[IV\], ocrelizumab IV) or PPMS (ocrelizumab IV).

Conditions

Multiple Sclerosis

Study ID

NCT07609719

Start date

Sep 2, 2026

Status verified date

Sep, 2026

Completion date

Feb 28, 2029

Anticipated

Primary completion date

Feb 28, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of RMS or PPMS according to the revised McDonald 2017 criteria
  • Documented Expanded Disability Status Scale (EDSS) score of 0-6.5, inclusive, at screening (or within 6 months of screening)
  • Participants discontinuing aCD20 therapy for reasons including, but not limited to, physician/participant preference, access to commercial drug (e.g., insurance coverage issues), or other logistical reasons (such as geographical relocation, travel, etc.) are eligible for this study
  • Prior treatment with ofatumumab SC, ublituximab-xiiy IV, or ocrelizumab IV aCD20 therapy

Exclusion Criteria:

  • Participants who have demonstrated suboptimal response to aCD20 therapy
  • Discontinuing aCD20 therapy because of any of the following treatment emergent adverse events (TEAEs): 1) Grade ≥3 severe infusion-related reaction (IRRs) or injection reactions (IRs); 2) Recurrent Grade ≥3 infections, or the need for ≥2 courses of antibiotics in the 12 months prior to screening, if the investigator believes infection is related to therapy
  • Participants with contraindication to Gd+ and participants who for any reason cannot tolerate MRI procedure
  • Known presence of active, recurrent, or chronic infection (e.g., human immunodeficiency virus \[HIV\], syphilis, human papillomavirus \[HPV\], tuberculosis \[TB\])
  • History of confirmed or suspected progressive multifocal leukoencephalopathy (PML)
  • Known presence of neurologic disorders that may interfere with the diagnosis of RMS or PPMS
  • Any concomitant disease that may require treatment with systemic corticosteroids (e.g., mineralocorticoids and glucocorticoids) or immunosuppressants during the study
  • Known allergy or hypersensitivity to ocrelizumab, rHuPH20, or excipients of the OCR SC formulation
  • Any previous treatment with bone marrow transplantation and hematopoietic stem cell transplantation
  • Treatment with any live-attenuated vaccine within 6 weeks prior to baseline
  • Treatment with any experimental procedures for RMS or PPMS (e.g., treatment for chronic cerebrospinal venous insufficiency)
  • Previous treatment with cladribine, atacicept, alemtuzumab or mitoxantrone
  • Positive hepatitis B virus (HBV) and hepatitis C virus (HCV) antibody test at screening

Other protocol defined inclusion and exclusion criteria may apply.

Study Design

Enrollment

100 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: OCR SC

Participants will receive OCR SC, 920 milligrams (mg) at Day 1 and at Week 24.

Interventions

OCR SC

Participants will receive OCR SC as per the schedule specified in the arm and the United States Prescribing Information (USPI).

Primary outcome measure

  • Percentage of Participants With no Change or Reduction From Baseline in Number of T1 Gadolinium-enhanced (Gd+) Lesions as Detected by Brain Magnetic Resonance Imaging (MRI) at Week 24 [ Time Frame: Baseline, Week 24 ]

Central Contacts and Locations

Central contacts

Reference Study ID Number: ML46740 https://forpatients.roche.com/ No attachments to email below.

888-662-6728 (U.S.)global-roche-genentech-trials@gene.com

Locations

Atlanta Neuroscience Institute

Recruiting

Atlanta, Georgia, United States, 30327

Neurology Clinic PC

Recruiting

Cordova, Tennessee, United States, 38108

More Information

Sponsor

Genentech, Inc.

Last update posted

Sep 8, 2026

Last verified

Sep, 2026

Keywords

  • Primary Progressive Multiple Sclerosis
  • Relapsing Multiple Sclerosis

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Genentech, Inc. on 2026-09-08.