Recruiting

Observational Study

Sponsor:

University of Rochester

Code:

NCT07614685

Conditions

Breathing

Lung Function Decreased

MRI Imaging

Healthy

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Airway Oscillometer

Phase Resolved Functional Lung MRI

Study Details

Brief summary:

This study will examine the relationship of airways resistance measured by oscillometry with ventilation defects measured by Phase Resolved Functional Lung (PREFUL) MRI in healthy human subjects.

Conditions

Breathing

Lung Function Decreased

MRI Imaging

Healthy

Study ID

NCT07614685

Start date

Sep 1, 2026

Status verified date

Sep, 2026

Completion date

Jan 1, 2028

Anticipated

Primary completion date

Jul 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age 18 years or older
  • Ability to provide consent
  • Willingness to perform MRI and breathing test
  • Must be able to speak and understand English

Exclusion Criteria:

  • Pregnant
  • Unable or willing to provide consent or perform the required maneuvers for testing.

Study Design

Enrollment

20 participants

Anticipated

Interventions and Outcome Measures

Arms

All participants

Interventions

Airway Oscillometer

The termoflo c-100 Airwave Oscillometer System is intended to measure respiratory system impedance using the Forced Oscillation Technique (FOT).

Phase Resolved Functional Lung MRI

The Phase Resolved Functional Lung (PREFUL) MRI technique acquires images of the lung so that measures of ventilatory defect percentage can be calculated.

Primary outcome measure

  • Oscillometer [ Time Frame: Single measurement, approximately 1 day ]
  • Phase Resolved Functional Lung (PREFUL) MRI [ Time Frame: Single measurement, approximately 1 day ]

Central Contacts and Locations

Central contacts

Patrick Donohue, MD

585-210-9301patrick_donohue@urmc.rochester.edu

Locations

University of Rochester Medical Center

Recruiting

Rochester, New York, United States, 14642

Contacts

Partick Donohue, MD

585-210-9301patrick_donohue@urmc.rochester.edu

More Information

Sponsor

University of Rochester

Last update posted

Sep 11, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-12. This information was provided to ClinicalTrials.gov by University of Rochester on 2026-09-11.