Recruiting
Phase 2

EVO756

Sponsor:

Evommune, Inc.

Code:

NCT07616128

Conditions

Migraine

Eligibility Criteria

Sex: All

Age: 18 - 64

Healthy Volunteers: Not accepted

Interventions

EVO756, Dose 1

EVO756, Dose 2

Placebo

Study Details

Brief summary:

This study will evaluate the efficacy and safety of EVO756 against placebo in adults with migraine.

Conditions

Migraine

Study ID

NCT07616128

Start date

Jul 29, 2026

Status verified date

Sep, 2026

Completion date

Nov, 2027

Anticipated

Primary completion date

Oct, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 64

Healthy Volunteers: Not accepted

Key Inclusion Criteria:

  • Adults aged 18 to <65 years
  • Migraine with or without aura, per ICHD-3 criteria
  • History of failure with prior preventive migraine treatments
  • Not currently using migraine preventive therapy

Key Exclusion Criteria:

  • Difficulty distinguishing migraine from other headache types or presence of other primary headache disorders
  • Use of certain medications
  • Any clinically significant medical, psychiatric, neurological, cardiovascular, or laboratory abnormalities

Study Design

Enrollment

330 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Dose 1

Orally administered EVO756, Dose 1 (Daily)

experimental: Dose 2

Orally administered EVO756, Dose 2 (Daily)

placebo comparator: Placebo

Placebo control (Daily)

Interventions

EVO756, Dose 1

Orally administered EVO756, Dose 1 (Daily)

EVO756, Dose 2

Orally administered EVO756, Dose 2 (Daily)

Placebo

Placebo Control (Daily)

Primary outcome measure

  • Mean change from baseline in the number of monthly migraine days (MMD) [ Time Frame: Last month of the 12-week treatment period ]

Central Contacts and Locations

Central contacts

Locations

Trialsphere Corp

Recruiting

Chandler, Arizona, United States, 85286

Contacts

Buena Park Research Center

Recruiting

Buena Park, California, United States, 90620

Contacts

EVO756-MIG001 Research Site

714-678-1700info@buenaparkresearch.com

Neuro Pain Research Center

Recruiting

Fresno, California, United States, 93710

Contacts

EVO756-MIG001 Research Site

5594379700lflores@neuropain.com

CA Medical Clinic for Headache

Recruiting

Los Angeles, California, United States, 90067

Contacts

EVO756-MIG001 Research Site

(323)879-9999jlatorre@clinicalri.net

Diablo Clinical Research dba Flourish Research

Recruiting

Walnut Creek, California, United States, 94598

Contacts

New England Institute for Neurology and Headache

Recruiting

Stamford, Connecticut, United States, 06905

Contacts

EVO756-MIG001 Research Site

203-914-1903annelise@neinh.com

Clinical Neuroscience Solutions, Inc.

Recruiting

Jacksonville, Florida, United States, 32256

Contacts

EVO756-MIG001 Research Site

904-281-5757bsagil@cnshealthcare.com

Apple Medical Research Group, Inc

Recruiting

Miami, Florida, United States, 331216

Contacts

EVO756-MIG001 Research Site

3056678434info@applemedresearch.org

Blessed Healthcase & Research

Recruiting

Miami, Florida, United States, 33173

Contacts

Florida Research Center, Inc.

Recruiting

Miami, Florida, United States, 33174

Contacts

EVO756-MIG001 Research Site

7865369009regulatory@floridarc.net

Clinical Neuroscience Solutions, Inc.

Recruiting

Orlando, Florida, United States, 32819

Contacts

Vantage Clinical Trials

Recruiting

Tampa, Florida, United States, 33614

Contacts

EVO756-MIG001 Research Site

8135495265ysanchez@vantagetrials.com

Premiere Research Institute at Palm Beach Neurology

Recruiting

West Palm Beach, Florida, United States, 33407

Contacts

Accel Research Site-Decatur-Alcanza

Recruiting

Decatur, Georgia, United States, 30030

Contacts

Mass Institute of Clinical Research

Recruiting

Westborough, Massachusetts, United States, 01581

Contacts

EVO756-MIG001 Research Site

9786843011research@micr.life

Michigan Headache and Neurological Institute

Recruiting

Ann Arbor, Michigan, United States, 48104

Contacts

EVO756-MIG001 Research Site

734-677-6000research@mhni.com

Quest Research Institute-Alcanza

Recruiting

Farmington Hills, Michigan, United States, 48334

Contacts

EVO756-MIG001 Research Site

2489578940Denise.Morgott@questri.com

Bio Behavoural health

Recruiting

Toms River, New Jersey, United States, 08755

Contacts

Clinosis - Dent Neurologic Instite

Recruiting

Amherst, New York, United States, 14226

Contacts

EVO756-MIG001 Research Site

716-250-2017abryan@dentinstitute.com

Asheville Neurology Specialists, Pa

Recruiting

Asheville, North Carolina, United States, 28806

Contacts

EVO756-MIG001 Research Site

(828) 210-9306amberc@ashneuro.com

Eximia Research NC

Recruiting

Raleigh, North Carolina, United States, 27607

Contacts

Clinical Trials of South Carolina

Recruiting

Charleston, South Carolina, United States, 29406

Contacts

EVO756-MIG001 Research Site

843-725-5067Info@clinicaltrialssc.com

FutureSearch Trials of Neurology

Recruiting

Austin, Texas, United States, 78731

Contacts

EVO756-MIG001 Research Site

(512) 380-9925ATXClinic@fstrials.com

FutureSearch Trials of Dallas

Recruiting

Dallas, Texas, United States, 75251

Contacts

EVO756-MIG001 Research Site

214-361-7700dallasleads@fstrials.com

SFF Medical Research Group LLC

Recruiting

Houston, Texas, United States, 77018

Contacts

EVO756-MIG001 Research Site

(832) 533-8872nichole.baio@evommune.com

Vaught Neurological Services

Recruiting

Crab Orchard, West Virginia, United States, 25827

Contacts

More Information

Sponsor

Evommune, Inc.

Last update posted

Sep 3, 2026

Last verified

Sep, 2026

Keywords

  • Migraine Disease
  • Migraine Disorder
  • Migraine Disorders
  • Migraine Headache
  • Migraine Headaches
  • Migraine
  • Migraines
  • Migraine in Adults
  • Migraine Prophylaxis
  • Migraine With Aura
  • Migraine With or Without Aura
  • Migraine With and Without Aura
  • Migraine Without Aura
  • Episodic Migraine Headache
  • Chronic Migraine Headache

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-26. This information was provided to ClinicalTrials.gov by Evommune, Inc. on 2026-09-03. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.