Recruiting

Right Ventricular Function

Sponsor:

Laval University

Code:

NCT07619274

Conditions

Respiratory Acidosis in ICU Patients

Right Ventricular (RV) Dysfunction

Hemodynamic Changes

Mechanical Ventilation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Not applicable- observational study

Study Details

Brief summary:

Right heart dysfunction remains a frequent cause of morbidity and mortality after cardiac surgery. Respiratory acidosis, particularly when accompanied by hypoxemia, plays a significant role in right heart failure, primarily by increasing right ventricular afterload through pulmonary vasoconstriction and elevated pulmonary arterial pressures. This phenomenon leads to increased right ventricular workload, causing dilation, decreased contractility, and ultimately right heart failure. The study aims to evaluate the effect of respiratory acidosis on right ventricular function after cardiac surgery.

Conditions

Respiratory Acidosis in ICU Patients

Right Ventricular (RV) Dysfunction

Hemodynamic Changes

Mechanical Ventilation

Study ID

NCT07619274

Start date

Jul 20, 2026

Status verified date

Nov, 2026

Completion date

Jun, 2027

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Previously included and complete study NCT05886413 or NCT06826794

Exclusion Criteria:

  • Absence of one or more of the following hemodynamic measurements: systolic or diastolic pulmonary artery pressure, central venous pressure, cardiac output
  • Absence of arterial blood gas on arrival to the intensive care unit

Study Design

Enrollment

220 participants

Anticipated

Interventions and Outcome Measures

Arms

Retrospective cohort

Completed study. Adult patients who underwent cardiac surgery were included if they were admitted to the intensive care unit immediately after surgery, mechanically ventilated in controlled mode, and had an arterial blood gas within the first hour following admission.

Prospective cohort

Completed study. Adult patient included on open-label randomized study, comparing clinician-chosen initial mechanical ventilation parameters to those recommended by an algorithm immediately after ICU admission.

Interventions

Not applicable- observational study

No intervention

Primary outcome measure

  • Right ventricular function per central hemodynamic assessment [ Time Frame: At intensive care unit admission - within the first 4 hours ]

Central Contacts and Locations

Central contacts

Etienne Couture

1-418-656-8711etienne.couture.3@ulaval.ca

Locations

Institut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval

Recruiting

Québec, Quebec, Canada, G1V4G5

Contacts

Etienne Couture

418-656-8711etienne.couture.3@ulaval.ca

More Information

Sponsor

Laval University

Last update posted

Nov 5, 2026

Last verified

Nov, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-06. This information was provided to ClinicalTrials.gov by Laval University on 2026-11-05. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.