Recruiting

Avocados

Sponsor:

Clinical Nutrition Research Center, Illinois Institute of Technology

Code:

NCT07624500

Conditions

Prediabetes

Insulin Resistance

Triglycerides

Lipids Metabolism

Eligibility Criteria

Sex: All

Age: 40 - 70

Healthy Volunteers: Accepted

Interventions

Avocado meal plan

Control meal plan

Study Details

Brief summary:

In this study, Investigators are interested in looking at the influence of eating avocados regularly, which are rich in healthy fats, fibers, and unique carbohydrates, on triglyceride and glucose metabolism in people with prediabetes and insulin resistance.

Conditions

Prediabetes

Insulin Resistance

Triglycerides

Lipids Metabolism

Study ID

NCT07624500

Start date

Jun 3, 2026

Status verified date

Jun, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Jun 28, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40 - 70

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Men or women, 40-70 years of age.
  • Fasting triglycerides (TG) >115 mg/dL.
  • Insulin resistance as measured by Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) >2.5.
  • Able to provide informed consent.
  • Able to comply with and perform the procedures requested by the protocol, specifically eat all the meals and snacks provided by the study which will be almost all your food (\~ 80% of calories per day).
  • Able to come to the clinic up to 6 times during the study.
  • Able to maintain usual physical activity pattern.
  • Able to avoid/abstain from alcohol and vigorous physical activity for 24 hours prior to and during study visit.

Exclusion Criteria:

  • Men and women with known or suspected intolerance, allergies or hypersensitivity to study foods or interventions.
  • Fasting blood sugar ≥125 mg/dL. Men and women with blood pressure >160 mmHg (systolic) / 100 mmHg (diastolic) at the screening visit.
  • Men and women with history of diabetes cardiovascular events, respiratory, renal, gastrointestinal, hepatic or eye disease or surgery- within a year.
  • Men and women who have or had cancer other than non-melanoma skin cancer in the past 5 years.
  • Men and women taking over the counter or prescription medications or dietary supplements that may interfere with study procedures or endpoints.
  • Men and women who are on a specialized diet (vegan, vegetarian, keto, etc.). - - Men and women who consume nuts or peanuts daily or most days of the week.
  • Men and women who are not weight stable (+/-10lbs in previous 2 months). Men and women who have excessive use of drugs or alcohol (ie., addictions) within the past 2 years.
  • Men and women with documented physical or mental disease/condition, which might limit participation in or completion of the study or, that, in the opinion of the investigator, could interfere with the interpretation of the study results.
  • Women who are known to be pregnant or who are intending to become pregnant over the course of the study.
  • Women who are lactating.
  • Major trauma or a surgical event within 2 months (or longer depending on trauma or event) and after consultation with PI. Has used antibiotics within the previous 2 months.
  • History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional.
  • Excessive coffee and tea consumers (> 4 cups/d).
  • Donated blood within the last 3 months.
  • Women who are taking an unstable dose and brand of hormonal contraceptives and/or a stable dose and brand for less than 6 months.
  • Unusual working hours (working overnight).

Study Design

Enrollment

82 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

active comparator: Avocado meal plan

2 meals and snack per day including one avocado in the meal, covering 80% of daily calories need.

placebo comparator: Control meal plan

2 meals and snacks per day without the inclusion of avocado, covering 80% of daily calories needs.

Interventions

Avocado meal plan

American Diet with avocado

Control meal plan

American diet

Primary outcome measure

  • Changes in serum biomarker: triglycerides [ Time Frame: baseline and 4 weeks ]

Central Contacts and Locations

Central contacts

Chelsea Preiss, MS

312-567-5300cpreiss@illinoistech.edu

Indika Edirisinghe, PhD

708-563-8178iedirisi@illinoistech.edu

Locations

Clinical Nutrition Research Center at IIT

Recruiting

Chicago, Illinois, United States, 60616

More Information

Sponsor

Clinical Nutrition Research Center, Illinois Institute of Technology

Last update posted

Jul 1, 2026

Last verified

Jun, 2026

Keywords

  • Triglycerides
  • Insulin resistance
  • Glucose metabolism
  • Lipids metabolism

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Clinical Nutrition Research Center, Illinois Institute of Technology on 2026-07-01.