Recruiting

Prednisone vs. Steroid

Sponsor:

Columbia University

Code:

NCT07630896

Conditions

Osteoarthritis

Unicompartmental Knee Arthroplasty

Total Hip Arthroplasty (THA)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Prednisone

Continuous Glucose Monitor

InkWell Health Tattoos

Study Details

Brief summary:

This study compares the efficacy of a 5-day post-operative oral prednisone regimen (40 mg daily) with the standard intraoperative steroid regimen, focusing on pain, swelling, range of motion, opioid use, and glucose levels monitored continuously.

Conditions

Osteoarthritis

Unicompartmental Knee Arthroplasty

Total Hip Arthroplasty (THA)

Study ID

NCT07630896

Start date

Jun 22, 2026

Status verified date

Sep, 2026

Completion date

Mar, 2028

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Undergoing Primary Unicompartmental Knee Arthroplasty or Total Hip Arthroplasty
  • Age 18 and above

Exclusion Criteria:

  • Steroid therapy
  • Narcotic use within past 3 months
  • History of corticosteroid intolerance
  • Pregnancy
  • Uncontrolled diabetes
  • Doesn't own smart phone

Drop Criteria:

\- 2nd dose of IV dexamethasone

Study Design

Enrollment

104 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Post-operative Steroids

Participants will receive a 5-day regimen of 40 mg oral prednisone postoperatively.

placebo comparator: Standard of care

Participants will receive standard of care treatment, consisting of the intravenous administration of dexamethasone and periarticular administration of steroids intraoperatively.

Interventions

Prednisone

40 mg daily for 5 days

Continuous Glucose Monitor

Provides real-time glucose readings for up to 14 days

InkWell Health Tattoos

Temporary medical-grade tattoos that provide real-time monitoring of knee swelling and range of motion

Primary outcome measure

  • Pain at Rest [ Time Frame: 2 weeks ]
  • Pain with Ambulation [ Time Frame: 2 weeks ]

Central Contacts and Locations

Central contacts

Jacqueline Lenahan

(212) 305-8193jl5092@cumc.columbia.edu

Locations

Columbia University Irving Medical Center

Recruiting

New York, New York, United States, 10032

Principal Investigator:

Roshan Shah, MD

More Information

Sponsor

Columbia University

Last update posted

Sep 24, 2026

Last verified

Sep, 2026

Keywords

  • Post-operative pain
  • Prednisone
  • Continuous Glucose Monitoring

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-25. This information was provided to ClinicalTrials.gov by Columbia University on 2026-09-24. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.