Recruiting

Image-Guided Training

Sponsor:

Georgetown University

Code:

NCT07635329

Conditions

Visual Field Defect

Stroke

Hemianopia Homonymous

Quadrantanopia

Cortical Blindness

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

High-level perceptual learning-based training

Low-level perceptual learning-based training

Study Details

Brief summary:

The BRIGHT (Behavioral Rehabilitation Through Image-Guided Home-based Training) study aims to evaluate the effectiveness of image-guided, home-based perceptual training at improving visual performance in individuals with visual field loss.

Using a prospective, crossover design, BRIGHT combines visual behavioral testing, neuroimaging, and a home-based intervention. It aims to 1) identify neural pathways that support training-induced visual plasticity; and 2) compare the efficacy of different types of visual training delivered in a home-based setting.

Conditions

Visual Field Defect

Stroke

Hemianopia Homonymous

Quadrantanopia

Cortical Blindness

Study ID

NCT07635329

Start date

Jul 23, 2026

Status verified date

Sep, 2026

Completion date

Mar 31, 2030

Anticipated

Primary completion date

Mar 31, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. At least 18 years of age.
2. Capable of providing informed consent and complying with study procedures.
3. Unilateral or bilateral focal brain damage causing visual field loss.
4. At least three months post-stroke or traumatic brain injury, or a stable brain tumor within the past year.
5. Eligible for MRI based on standard safety screening.

Exclusion Criteria:

1. Severe neurological or psychiatric conditions unrelated to the focal lesion that may interfere with study participation or data interpretation.
2. Current or recent (within the past 6 months) drug or alcohol abuse or addiction as defined by DSM-5.
3. Ocular disease or disorder.

Study Design

Enrollment

100 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Perceptual learning-based training using high-level visual stimuli

A 3 week at-home online perceptual learning-based training using high-level visual stimuli.

active comparator: Perceptual learning-based training using low-level visual stimuli

A 3 week at-home online perceptual learning-based training using low-level visual stimuli.

Interventions

High-level perceptual learning-based training

Behavioral intervention consisting of repeated computerized visual discrimination tasks targeting higher-order visual processing

Low-level perceptual learning-based training

behavioral intervention consisting of repeated computerized visual discrimination tasks targeting low-level visual processing

Primary outcome measure

  • Change in high-level perceptual discrimination performance [ Time Frame: Week 2-4 or Week 7-9 of the study (depending on the order) ]
  • Change in low-level perceptual discrimination performance [ Time Frame: Week 2-4 or Week 7-9 of the study (depending on the order) ]

Central Contacts and Locations

Central contacts

Tina Liu, PhD

2027849920tina.liu@georgetown.edu

Locations

Georgetown University Medical Center

Recruiting

Washington D.C., District of Columbia, United States, 20057

Contacts

Tina Liu, PhD

202-784-9949vpplab@georgetown.edu

Principal Investigator:

Tina Liu, PhD

More Information

Sponsor

Georgetown University

Last update posted

Sep 14, 2026

Last verified

Sep, 2026

Keywords

  • neuroplasticity
  • stroke
  • vision
  • TBI
  • brain tumor

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-28. This information was provided to ClinicalTrials.gov by Georgetown University on 2026-09-14. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.