Recruiting

Alcohol Sensitivity

Sponsor:

University of Florida

Code:

NCT07636447

Conditions

Healthy Adult Participants

Eligibility Criteria

Sex: All

Age: 65 - 70+

Healthy Volunteers: Accepted

Interventions

Alcohol (Oral)

Placebo Control

Study Details

Brief summary:

This is a proof-of-concept study exploring individual differences in sensitivity to alcohol among older healthy current drinkers aged 65 to 80. Participants will complete two sessions during which they will complete questionnaires and laboratory measures of mental abilities and brain activity and receive a beverage that may or may not contain a moderate dose of alcohol.

Conditions

Healthy Adult Participants

Study ID

NCT07636447

Start date

Oct 3, 2026

Status verified date

May, 2026

Completion date

Jun, 2028

Anticipated

Primary completion date

Jun, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 65 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria

  • Alcohol Drinkers who consume alcohol on a regular basis
  • No history of significant substance misuse
  • at least 12 years of education or GED equivalence Exclusion Criteria
  • current Cigarette smoker
  • Type 1 Diabetes or uncontrolled Type 2 Diabetes
  • Epilepsy
  • Neurodegenerative disorder
  • Significant psychiatric disorder such as a psychotic disorder, bipolar disorder, current major depression or PTSD

Study Design

Enrollment

80 participants

Anticipated

Allocation

Non randomized

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Alcohol Condition

Beverage contains an alcohol volume consistent with achieving a sub-intoxicating breath alcohol concentration

placebo comparator: Non-Alcohol Session

Placebo beverage is administered

Interventions

Alcohol (Oral)

Described elsewhere

Placebo Control

on each of two visits, participants receive either the placebo drink or the drinking containing alcohol

Primary outcome measure

  • Alcohol Effects on Psychomotor Skills as reflected in the Trail Making Test (TMT) [ Time Frame: The placebo and alcohol sessions occur ~ 10-14 days apart. ]
  • Alcohol Effects on a Working Memory Task requiring Continuous Recognition [ Time Frame: The placebo and alcohol sessions occur ~ 10-14 days apart. ]
  • Alcohol Effects on Neural Activity Measured from Scalp Electroencephalography [ Time Frame: The alcohol and placebo sessions occur ~ 10-14 days apart. ]

Central Contacts and Locations

Central contacts

Sara Jo Nixon, PhD

352-294-4920sjnixon@ufl.edu

Ben Lewis, PhD

352-294-4920benlewis@ufl.edu

Locations

University of Florida

Recruiting

Gainesville, Florida, United States, 32610

Contacts

Sara Jo Nixon, PhD

352-294-4920sjnixon@ufl.edu

Ben Lewis, PhD

35222944920benlewis@ufl.edu

Principal Investigator:

Sara Jo Nixon, PhD

More Information

Sponsor

University of Florida

Last update posted

Sep 30, 2026

Last verified

May, 2026

Keywords

  • Older adults, alcohol drinkers, cognition

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-01. This information was provided to ClinicalTrials.gov by University of Florida on 2026-09-30. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.