Recruiting

Exercise Training

Sponsor:

Indiana University

Code:

NCT07637331

Conditions

Respiratory Muscle Training

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Interventions

Inspiratory muscle training

Study Details

Brief summary:

Determine if exercise training for the respiratory muscles improves cognitive performance during periods when breathing against a resistance.

Conditions

Respiratory Muscle Training

Study ID

NCT07637331

Start date

Mar 27, 2026

Status verified date

Jun, 2026

Completion date

Apr, 2027

Anticipated

Primary completion date

Apr, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18-40 years old
  • Body mass index <30 kg/m2
  • Naïve to IMT
  • >75% of predicted forced expiratory volume in 1 second (FEV1) / forced vital capacity (FVC) (FEV1/FVC)
  • Access to smart phone or tablet with internet

Exclusion Criteria:

  • Diagnosed:

  • Cardiovascular disease
  • Respiratory disease (including asthma)
  • Metabolic disease
  • Currently pregnant
  • Unable to adhere to the IMT protocol
  • Answering 'yes' to any of the questions on page one of the PAR-Q+
  • Abnormal cognition assessed via the Montreal Cognitive Assessment (score of 25 or less)
  • Self-reported color blindness
  • Significant acute or chronic medical, neurologic, or illness in the participant that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability of the participant to complete the study, and/or compromise the objectives of the study

Study Design

Enrollment

32 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Active IMT

Inspiratory muscle training

sham comparator: Sham IMT

Sham inspiratory muscle training

Interventions

Inspiratory muscle training

8 weeks of active or sham inspiratory muscle training

Primary outcome measure

  • Diaphragm thickness [ Time Frame: Baseline and after 8 weeks of training ]
  • Cognitive performance [ Time Frame: Baseline and after 8 weeks of training ]

Central Contacts and Locations

Central contacts

Blair Johnson

812-855-8699bj33@iu.edu

Locations

Indiana University

Recruiting

Bloomington, Indiana, United States, 47405

Contacts

Blair Johnson, PhD

812-855-8699bj33@iu.edu

Principal Investigator:

Blair Johnson, PhD

More Information

Sponsor

Indiana University

Last update posted

Jun 26, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Indiana University on 2026-06-26.