Recruiting

HERO ComponentsTrial in HPV Prevention for the U.S. Vietnamese Community

Sponsor:

Northwestern University

Code:

NCT07637630

Conditions

HPV-related Cancers

HPV Vaccination

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Expert Video

Self-persuasion

Narrative Storytelling

Motivational Interviewing

Constant Component

Study Details

Brief summary:

The purpose of the HERO study is to leverage the Multiphase Optimization Strategy (MOST) framework to conduct a pilot trial testing four different intervention components (expert video, self-persuasion, narrative storytelling, and motivational interviewing) targeting HPV vaccination among U.S. Vietnamese.

PRIMARY AIM To assess the feasibility and acceptability of each of the four digital HERO intervention components in a pilot optimization trial using the MOST framework. Using a highly efficient design, the study team will randomize 96 Vietnamese parents of unvaccinated adolescents to receive 0 to 4 HERO components. The study team will establish the feasibility (reach, retention, adherence) and acceptability (usability, satisfaction, usefulness, cultural relevance) of each component (expert video, self-persuasion, narrative storytelling, and motivational interviewing).

SECONDARY AIM To investigate effects of each component on HPV vaccination outcomes and psychosocial mediators. The study team will examine the effects on HPV vaccination (initiation and intention) and psychosocial mediators.

Conditions

HPV-related Cancers

HPV Vaccination

Study ID

NCT07637630

Start date

May 1, 2026

Status verified date

Jun, 2026

Completion date

Jun 30, 2029

Anticipated

Primary completion date

Jun 30, 2029

Anticipated

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

Self-identify as U.S. Vietnamese.
Are the parent of a youth ages 9-18 who have not initiated the HPV vaccine series. Only one parent per household will be able to participate.
Have lived in the U.S. for 12 months or more.

Exclusion Criteria:

Planning to move out of the U.S. within the next 6 months.
Not fluent in either spoken and written Vietnamese or spoken and written English.
Inability to provide informed consent.

Study Design

Enrollment

96 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Experimental: Exp Condition 1

Research participant receives the Constant component + Expert video + Self-persuasion + Narrative storytelling + Motivational interviewing

experimental: Experimental: Exp Condition 2

Research participant receives Constant + Expert video + Self-persuasion + Narrative storytelling.

experimental: Experimental: Exp Condition 3

Research participant receives Constant + Expert video + Self-persuasion + Motivational interviewing

experimental: Experimental: Exp Condition 4

Research participant receives Constant + Expert video + Self-persuasion

experimental: Experimental: Exp Condition 5

Research participant receives Constant + Expert video + Narrative storytelling + Motivational interviewing

experimental: Experimental: Exp Condition 6

Research participant receives Constant + Expert video + Narrative storytelling

experimental: Experimental: Exp Condition 7

Research participant receives Constant + Expert video + Motivational interviewing

experimental: Experimental: Exp Condition 8

Research participant receives Constant + Expert video

experimental: Experimental: Exp Condition 9

Research participant receives Constant + Self-persuasion + Narrative storytelling + Motivational interviewing

experimental: Experimental: Exp Condition 10

Research participant receives Constant + Self-persuasion + Narrative storytelling

experimental: Experimental: Exp Condition 11

Research participant receives Constant + Self-persuasion + Motivational interviewing

experimental: Experimental: Exp Condition 12

Research participant receives Constant + Self-persuasion

experimental: Experimental: Exp Condition 13

Research participant receives Constant + Narrative storytelling + Motivational interviewing

experimental: Experimental: Exp Condition 14

Research participant receives Constant + Narrative storytelling

experimental: Experimental: Exp Condition 15

Research participant receives Constant + Motivational interviewing

experimental: Experimental: Exp Condition 16

Research participant receives the Constant component only

Interventions

Expert Video

Participants will watch a video featuring Vietnamese healthcare providers. In the video, the providers will endorse vaccine safety and efficacy, dispel common misconceptions or concerns, and use verbal persuasion techniques to recommend HPV vaccination.

Self-persuasion

Participants will complete an interactive web-based task where they audio record reasons, summarized in their own words, for getting their adolescent the HPV vaccine.

Narrative Storytelling

Participants will watch a video featuring U.S. Vietnamese parents. In the video, featured parents will describe stories of their experiences learning about the HPV vaccine as well as motivations to initiate and complete the vaccine series on-time for their adolescents.

Motivational Interviewing

Participants will receive 2 calls (phone or Zoom) from a trained U.S. Vietnamese health educator. The health educator will use motivation interviewing (e.g., open-ended questions, acknowledging feelings, affirmations, reflective listening) to increase opportunities for and commitment to HPV vaccination while decreasing barriers (e.g., safety or access concerns).

Constant Component

Each participant will receive the constant component through the study website, which includes a vaccine information statement from the CDC with details on HPV vaccine benefits, potential side effects, and recommended vaccination schedule, as well as online information on access and locations for HPV vaccine (e.g., list of Vaccines for Children providers where Medicaid, uninsured, or underinsured adolescents can be vaccinated for free).

Primary outcome measure

Feasibility: Reach [ Time Frame: Baseline ]
Feasibility: Retention [ Time Frame: 1, 3, and 6 months post-randomization ]
Feasibility: Adherence [ Time Frame: 1-month post randomization ]
Acceptability [ Time Frame: 1-month post randomization ]

Central Contacts and Locations

Central contacts

Milkie Vu

312-503-6592 milkie.vu@northwestern.edu

Ninh Nguyen

ninh.nguyen@northwestern.edu

Locations

Northwestern University

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Milkie Vu

312-503-6592 milkie.vu@northwestern.edu

Ninh Nguyen

ninh.nguyen@northwestern.edu

More Information

Sponsor

Northwestern University

Last update posted

Jun 11, 2026

Last verified

Jun, 2026

Keywords

HPV vaccination
digital health intervention
U.S. Vietnamese
MOST framework
behavioral intervention
adolescent vaccination

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Northwestern University on 2026-06-11.