Recruiting

Cryoneurolysis

Sponsor:

Yale University

Code:

NCT07639060

Conditions

Chronic Pain

PERIPHERAL NEUROPATHY

Occipital Neuralgia

Chronic Hip Pain

Hip Osteoarthritis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.

Conditions

Chronic Pain

PERIPHERAL NEUROPATHY

Occipital Neuralgia

Chronic Hip Pain

Hip Osteoarthritis

Study ID

NCT07639060

Start date

Jun 20, 2026

Status verified date

Aug, 2026

Completion date

Jul, 2028

Anticipated

Primary completion date

Jul, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of chronic pain (generally pain duration of at least 3-6 months) localized to an anatomical region appropriate for cryoneurolysis as determined by the treating physician.
  • Planned cryoneurolysis procedure as part of standard clinical care.
  • Ability to provide written informed consent.
  • Ability and willingness to complete baseline and follow-up questionnaires.

Exclusion Criteria:

  • Cryoneurolysis performed as part of a separate investigational trial in which data sharing is not permitted.
  • Active infection or other clinical contraindication to the procedure as determined by the treating clinician.
  • Life expectancy of less than 12 months in the judgment of the treating clinician.
  • Any condition that, in the investigator's opinion, would interfere with study participation or completion of follow-up, such as severe psychiatric instability or active substance use that precludes reliable follow-up

Study Design

Enrollment

80 participants

Anticipated

Interventions and Outcome Measures

Arms

Participants undergoing cryoneurolysis

Participants undergoing cryoneurolysis for chronic pain as part of standard clinical care.

Primary outcome measure

  • Percentage of participants with improvement in pain [ Time Frame: 6 and 12 months ]
  • Change in Pain Disability Index (PDI) score [ Time Frame: 6 and 12 months ]

Central Contacts and Locations

Central contacts

Charles A Odonkor, MD

203-767-1555charles.odonkor@yale.edu

Muhammad U Siddique, MD

muhammad.siddique@yale.edu

Locations

Yale New Haven Health Old Saybrook Medical Center

Recruiting

Old Saybrook, Connecticut, United States, 06475

More Information

Sponsor

Yale University

Last update posted

Aug 21, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Yale University on 2026-08-21.