Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT07641413

Conditions

Pollution Related Respiratory Disorder

Pollution; Exposure

Dyspnea

Cardiopulmonary

Eligibility Criteria

Sex: All

Age: 24 - 68

Healthy Volunteers: Accepted

Interventions

Healthy control

Study Details

Brief summary:

The main objective of this study is to develop baseline "normal" reference values of both lung and heart function for healthy adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations.

This study will involve performing key components of the Department of Veterans Affairs the Airborne Hazards and Open Burn Pit Center of Excellence (AHOBPCE) and a VA network of Post-Deployment Cardiopulmonary Evaluation Network (PDCEN) Core Clinical Evaluation in asymptomatic unexposed healthy controls without known lung or heart disease to serve as a "normal" control comparator group for veterans evaluated by PDCEN.

Conditions

Pollution Related Respiratory Disorder

Pollution; Exposure

Dyspnea

Cardiopulmonary

Study ID

NCT07641413

Start date

Aug 1, 2024

Status verified date

Jun, 2026

Completion date

Dec 31, 2030

Anticipated

Primary completion date

Dec 31, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 24 - 68

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age 24-68
  • No respiratory complaints (defined as modified Medical Research Council score = 0)
  • No use of respiratory medications

Exclusion Criteria:

  • Non-English speaking
  • Pregnancy
  • BMI>35 Kg/m2
  • Tobacco smoking within prior year
  • Lifetime tobacco smoking of >5 pack-years
  • Current inhaled cannabis use (any modality) >2x weekly
  • Prior inhaled cannabis uses exceeding 2x weekly within the prior year
  • Illicit drug use (other than cannabis)
  • No prior or current major organ disease, including but not limited to:

  • Neuromuscular weakness
  • History of malignancy (other than non-melanoma skin cancer)-- HIV/AIDS
  • Autoimmune disease
  • Solid-organ or hematopoietic stem cell transplant
  • Cardiovascular disease (other than mild HTN; < 140/90; controlled on 2 or less medications)

  • Poorly-controlled HTN (SBP>140 or DBP>90 or use of more than 2 anti-hypertensive medications)
  • Any history of congestive heart failure (CHF, either HFpEF or HFrEF)
  • Any history of arrythmia (including atrial fibrillation)

Study Design

Enrollment

200 participants

Anticipated

Interventions and Outcome Measures

Interventions

Healthy control

Observational study with no intervention

Primary outcome measure

  • Normal reference values for heart and lung function within the age range relevant to the United States Veteran population. [ Time Frame: 2 years ]
  • Normal reference values for heart and lung function within the age range relevant to the United States Veteran population. [ Time Frame: 2 years ]
  • Normal reference values for heart and lung function within the age range relevant to the United States Veteran population. [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

Mehrdad Arjomandi, MD

415-221-4810mehrdad.arjomandi@ucsf.edu

Locations

University of California San Francisco

Recruiting

San Francisco, California, United States, 94143

Contacts

Mehrdad Arjomandi, MD

415-221-4810mehrdad.arjomandi@ucsf.edu

More Information

Sponsor

University of California, San Francisco

Last update posted

Jun 11, 2026

Last verified

Jun, 2026

Keywords

  • Cardiopulmonary function
  • Pulmonary function testing
  • Forced oscillometry testing
  • Echocardiography
  • Cardiopulmonary exercise testing
  • Computed tomography imaging

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-06-11.