Recruiting

MVM Supplementation

Sponsor:

UCLA

Code:

NCT07642869

Conditions

Healthy Aging

Multivitamin and Mineral Supplementation

Eligibility Criteria

Sex: All

Age: 40 - 60

Healthy Volunteers: Accepted

Interventions

MVM Core Blend

MVM Gold Blend

Placebo

Study Details

Brief summary:

The goal of this study is to determine the impact of MVM supplementation on clinical and biochemical markers associated with healthy aging, with a particular focus on mitochondrial function and metabolism. Specifically, changes in mitochondrial respiration using isolated blood cells will be measured. This method has been used to compare with various other age-related markers of health such as physical function, gait speed, and resting metabolic rate. It is hypothesize that MVM supplementation will impact the function of blood cells. MVM supplementation impacts other markers of health, including serum nutrient levels, metabolomic profiles, physical function, and skeletal muscle composition and quality will be explored. These comprehensive assessments will provide insights into the potential benefits of MVM supplementation for healthy aging and address critical gaps in our understanding of its immediate effects. Further, this study will aid in the understanding of how multivitamin supplements can support heathy aging in mid-life adults, a key time to start including wellness programs in people's lives.

The study cohort will consist of 150 sedentary men and women aged 40-60-years of age. A double-blind, three-arm, placebo-controlled randomized clinical trial will be conducted. Participants will receive a daily oral tablet containing one of two possible formulations of vitamins and minerals or a placebo. The three groups will be MVM "GOLD" blend formula, the US Restage MVM "US CORE", and the placebo group.

Conditions

Healthy Aging

Multivitamin and Mineral Supplementation

Study ID

NCT07642869

Start date

Sep 5, 2025

Status verified date

Jun, 2026

Completion date

Dec, 2026

Anticipated

Primary completion date

Oct, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40 - 60

Healthy Volunteers: Accepted

Inclusion Criteria:

1. IPAQ-SF categorical score of low or moderate physical activity (indicating sedentary lifestyle).
2. Stated willingness to comply with all study procedures and availability for the duration of the study
3. Between 40-60 years of age
4. BMI ≥18.5 and ≤32 kg/m2
5. Weight stable for the prior 6 weeks

Exclusion Criteria:

1. Is pregnant or nursing.
2. Current smoker.
3. Diabetes (FPG > 180 mg/dL or A1c>8)
4. Heart or cardiovascular condition, including coronary artery disease, congestive heart failure, diagnosed abnormality of heart rhythm, atrial fibrillation and/or a history of myocardial infarction
5. Cancer or history of cancer within the past 5 years
6. Sensory or physical impairment that would prevent participation
7. Parkinson's disease, multiple sclerosis or other neurological condition, including a previous stroke, that may be causing impaired muscle function or mobility
8. Consistent use of any multivitamin and mineral supplement use, or any supplement that may interfere with measurements or biological outcomes (including but not limited to: NAD+ supplements, MitoQ)
9. Individuals with drug interactions as determined by the study physician

Study Design

Enrollment

150 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: MVM Core Blend

This is a modification to currently marketed Centrum Adult in which select nutrients have been removed or lowered to provide a better consumer experience. This will be consumed once per day for the duration of the study.

experimental: MVM Gold Blend

Because Centrum is a global multivitamin/multimineral brand, it has numerous product formulations for different regions/markets around the world. To better harmonize these formulations across key markets, a 'core' blend of vitamins and minerals has been designed at levels that can be leveraged across different markets - this is internally being referred to as the MVM "GOLD" Blend formula. This will be consumed once per day for the duration of the study.

placebo comparator: Placebo

The placebo is a pill of the same color, size, and density as the experimental pills. It contains no vitamins or minerals. It will be administered once a day as the experimental pills.

Interventions

MVM Core Blend

Consists of a pill containing a 22-ingredient blend of vitamins and minerals

1 pill will be taken daily, 7 days/week for 12 weeks

MVM Gold Blend

Pills, participants will take contain a 17-ingredient blend of vitamins and minerals.

Instructions: 1 pill each day, 7 days/week for 12 weeks

Placebo

Pill contains no vitamins or minerals.

1 pill will be taken daily, 7 days/week, for 12 weeks

Primary outcome measure

  • PBMC Respiratory Capacity by Oxymetry [ Time Frame: From enrollment to the end of study at 14 weeks ]

Central Contacts and Locations

Central contacts

Lina Scandalis, PhD

18588226443Lscandalis@health.ucsd.edu

David Wing, PhD

8585349317dwing@health.ucsd.edu

Locations

University of California, San Diego

Recruiting

La Jolla, California, United States, 92093

Contacts

Lina Scandalis, PhD

18588226443Lscandalis@health.ucsd.edu

David Wing, PhD

dwing@health.ucsd.edu

Principal Investigator:

Anthony Molina, PhD

More Information

Sponsor

University of California, San Diego

Last update posted

Jun 15, 2026

Last verified

Jun, 2026

Keywords

  • Multivitamin and mineral supplements
  • Supplements
  • Cellular metabolism
  • healthy aging
  • mitochondria
  • Respirometry

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Diego on 2026-06-15.