Recruiting
Phase 1

Gepotidacin

Sponsor:

GlaxoSmithKline

Code:

NCT07645235

Conditions

Urinary Tract Infections

Eligibility Criteria

Sex: Female

Age: 18 - 50

Healthy Volunteers: Accepted

Interventions

Gepotidacin

Study Details

Brief summary:

This study aims to evaluate the pharmacokinetic of gepotidacin in fed healthy lactating women.

Conditions

Urinary Tract Infections

Study ID

NCT07645235

Start date

Jul 23, 2026

Status verified date

Sep, 2026

Completion date

May 17, 2027

Anticipated

Primary completion date

May 17, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 50

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Participants must be healthy lactating women, 18 to 50 years of age, inclusive, at Screening.
  • Actively breastfeeding or expressing breast milk.
  • At least 28 days postpartum with a full milk supply established, and with no persistent complications from delivery (there is no maximal length of time postpartum required).
  • Willingness to temporarily discontinue feeding breast milk to infants from dosing through to 72 hours after dosing (approximately 3 days), with the ability to pump and provide reserve milk for bottle feeding prior to the study OR has decided to permanently discontinue breastfeeding but has not started weaning, provided the infant accepts bottle feeding and a sufficient milk supply is maintained by pumping 3 to 4 times daily, considering changes in milk composition during weaning process.
  • Is willing to fully express breast milk from both breasts during the duration of the milk collection portion of the study. Participants must be able to express milk from each breast at each pumping session using a breast pump.
  • Has a body mass index (BMI) of less than or equal to (<=) 36 kilograms per meter square (kg/m\^2) and weighs at least 45 kilograms (kg) with all clinical assessments considered as clinically non-significant per investigator.
  • Non-smoker (including vaping) or prior smokers (having smoked less than 10 cigarettes per day) who have stopped smoking for at least 1 month prior to screening.
  • Understands the study procedures and is capable of providing written informed consent.
  • A negative highly sensitive pregnancy test (\[urine or serum\] as required by local regulations) will be required at Baseline before the dose of study intervention.

Exclusion Criteria:

  • Participant is unwilling or unable to comply with the study restrictions or lifestyle guidelines presented in the protocol during the study period and through the post study visit.
  • History or evidence of any clinically significant hematological, endocrine, pulmonary, gastrointestinal, cardiovascular, psychiatric (including post-natal depression), neurologic, infectious, neoplastic, active cancer or allergic disease (including drug allergies, but excluding untreated asymptomatic, seasonal allergies at time of dosing) or clinical findings that, in the opinion of the study investigator, might confound the results of the study or poses an additional risk to the participant or infant by participation in the study.
  • Has had major surgery in the past 3 months (except delivery through a C section and/or tubal ligation).
  • History of significant multiple and/or severe allergies (including latex allergy, but with exception of seasonal rhinitis \[hay fever\]) or has had an anaphylactic reaction or significant intolerability to prescription or non-prescription drugs or food.
  • Hypersensitivity to gepotidacin.
  • Current or recent (less than \[<\] 14 days) mastitis, or history of breast surgery (augmentation or reduction).
  • Use of any QT prolonging medications within 7 days prior to first dose, use of strong or moderate Cytochrome P450 3A4 (CYP3A4) inhibitors within 7 days prior to first dose, or use of strong or moderate CYP3A4 inducers (including vitamins, herbal and dietary supplements such as St. John's wort) within 14 days prior to first dose.
  • Currently a user of illicit drugs or has a history of drug (including alcohol) abuse within approximately 1 year.
  • Donated or lost 1 unit of blood (approximately 500 milliliters \[mL\]) or participated in another investigational study within 30 days or 5 half-lives of the investigational product prior to the screening. The 30 days window will be derived from the date of the last study procedure (i.e., poststudy, AE follow-up, etc.) in the previous study to the screening visit of the current study.
  • The participant has participated in a clinical trial and has received an investigational product within 30 days or 5 half-lives, whichever is longer.
  • Participants with excessive caffeine intake (defined as greater than \[>\] 6 servings \[1 serving is approximately equivalent to 120 milligram \[mg\] of caffeine\] of coffee, tea, cola or other caffeinated beverages per day) within 14 days prior to first dose.
  • The participant has known severe renal impairment (creatinine clearance <30 milliliters per minute \[mL/min\] or clinically significant elevated serum creatinine as determined by the investigator).
  • The participant presents with (self-reported) vaginal discharge suspected for infection at Baseline.
  • The participant has congenital long QT syndrome or known prolongation of the corrected QT (QTc) interval.
  • The participant has a family history of QT prolongation or sudden death.
  • The participant has a recent history of vasovagal syncope or episodes of symptomatic bradycardia or brady arrhythmia within the last 12 months.
  • Having two or more of the following risk factors: 1. Body weight between 45 kg and 60 kg, 2. Moderate renal impairment (creatinine clearance 30 to 59 mL/min), 3. Moderate hepatic impairment (Child Pugh Class B)
  • QTc >450 milliseconds (msec) or QTc >480 msec for participants with bundle branch block.
  • Severe hepatic impairment (Child Pugh Class C)
  • Alanine aminotransferase >1.5\*upper limit of normal (ULN).
  • Total bilirubin >1.5\*ULN; Participants with Gilbert's syndrome can be included with total bilirubin >1.5\*ULN if direct bilirubin is <=1.5\*ULN.
  • Current or chronic history of liver disease or known hepatic or biliary abnormalities (except for Gilbert's syndrome or asymptomatic gallstones).

Study Design

Enrollment

8 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Participants receiving Gepotidacin

Interventions

Gepotidacin

A single oral dose of 3000 mg gepotidacin will be administered

Primary outcome measure

  • Area under the concentration-time curve from time zero to the last measurable concentration time point (t) (AUC[0 to t]) of gepotidacin in breast milk [ Time Frame: Up to 48 hours post dose ]

Central Contacts and Locations

Central contacts

US GSK Clinical Trials Call Center

877-379-3718GSKClinicalSupportHD@gsk.com

EU GSK Clinical Trials Call Center

+44 (0) 20 89904466GSKClinicalSupportHD@gsk.com

Locations

GSK Investigational Site

Recruiting

Las Vegas, Nevada, United States, 89113-2235

Contacts

US GSK Clinical Trials Call Center

877-379-3718GSKClinicalSupportHD@gsk.com

EU GSK Clinical Trials Call Centre

+44 (0) 20 8990 4466GSKClinicalSupportHD@gsk.com

Principal Investigator:

Darin Brimhall

More Information

Sponsor

GlaxoSmithKline

Last update posted

Sep 30, 2026

Last verified

Sep, 2026

Keywords

  • Gepotidacin
  • Pharmacokinetics
  • Healthy Lactating Women

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-01. This information was provided to ClinicalTrials.gov by GlaxoSmithKline on 2026-09-30. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.