Recruiting

IV CBCT

Sponsor:

University Health Network, Toronto

Code:

NCT07648160

Conditions

Advanced Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Intravenous contrast-enhanced cone beam computed tomography

Study Details

Brief summary:

This is a single-arm prospective, feasibility study evaluating the intravenous contrast-enhanced cone beam computed tomography (IV CBCT) for image guidance during radiotherapy. Patients treated with SFRT will receive IV-contrast enhanced CT and fMRI before treatment for simulation purposes. Additionally, patients will receive mpMRI just before and IV-contrast enhanced CBCT during their second and last fraction of RT, in addition to the standard of care CBCT that is acquired for daily image-guided patient positioning. Patients will undergo both IV-contrast enhanced CBCT and treatment on the TrueBeam with HyperSight imaging capability. We hypothesize IV contrast enhanced CBCT is feasible, well-tolerated by patients and improves the visibility of the target.

Conditions

Advanced Cancer

Study ID

NCT07648160

Start date

Jun 24, 2026

Status verified date

Jun, 2026

Completion date

Jul 1, 2027

Anticipated

Primary completion date

Jul 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Primary biopsy-proven cancer
  • Planning to undergo spatially fractionated radiation therapy
  • Able to provide informed consent
  • Willingness to participate in follow-up
  • ECOG less than or equal to 3
  • Normal creatinine (below 109mmol/L), normal eGF

Exclusion Criteria:

  • Unable to understand/provide consent
  • History of allergic reaction to iodinated IV contrast dye (allergy to MR contrast is not an exclusion criteria)
  • Known renal disease
  • Single kidney
  • Kidney transplant
  • Dialysis
  • Contraindication to MRI

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: IV CBCT

Interventions

Intravenous contrast-enhanced cone beam computed tomography

Two half-arc IV-contrast enhanced CBCT scans and mpMRI seuqences in addition to their routine standard of care CBCT that is done as part of image-guided radiotherapy. These scans will be done during the second and last fraction of treatment.

Primary outcome measure

  • Feasibility of IV-contrast enhanced CBCT during image-guided radiotherapy [ Time Frame: 18 Months ]

Central Contacts and Locations

Central contacts

Jelena Lukovic, MD FRCPC MPH MRMD

4169464501jelena.lukovic@uhn.ca

Locations

Princess Margaret Cancer Center

Recruiting

Toronto, Ontario, Canada, M5G 2M9

Contacts

Jelena Lukovic, MD FRCPC MPH MRMD

416-946-4501Jelena.Lukovic@uhn.ca

More Information

Sponsor

University Health Network, Toronto

Last update posted

Jun 26, 2026

Last verified

Jun, 2026

Keywords

  • IV-contrast-enhanced CT

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University Health Network, Toronto on 2026-06-26.