Recruiting

Mango vs. Sucrose

Sponsor:

Ball State University

Code:

NCT07650058

Conditions

Healthy Participants

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Interventions

High-Glycemic Breakfast Containing Cereal and Fresh Mango

High-Glycemic Breakfast Containing Cereal and Table Sugar

Study Details

Brief summary:

Systemic inflammation and intestinal hyperpermeability (disruption of the gut barrier which allows nutrient molecules and bacteria to enter the bloodstream) are triggered by consumption of high-sugar meals and are linked to future development of cardiovascular disease (CVD). Previous research indicates that fresh mangos have properties that have positive effects on the intestinal barrier and local gut inflammation. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to decreased inflammatory and permeability biomarkers after eating a high-sugar breakfast. The investigators will compare the postprandial (post meal) levels of inflammatory (IL-6) and permeability (LPS, lipid binding protein (LBP), and soluble CD14) biomarkers in blood from participants who have consumed a meal sweetened with either sucrose or fresh mango.

Conditions

Healthy Participants

Study ID

NCT07650058

Start date

Feb 1, 2026

Status verified date

Jun, 2026

Completion date

Jan, 2027

Anticipated

Primary completion date

Jul, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18 - 45 years.
  • Body mass index between 18.5-35.0 kg/m2
  • Not pregnant or expecting to become pregnant (females only)
  • Not postmenopausal (females only).
  • No known chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.)
  • No history of using tobacco/illicit drugs
  • No history of using glucose-lowering medications/supplements.
  • No history of using prescribed anti-inflammatory medications
  • Does not use over-the-counter anti-inflammatory medications ≥2x/week
  • Does not have a pacemaker.
  • No relevant food allergies/intolerances
  • Able to lay supine for at least ten minutes.

Exclusion Criteria:

  • Not between the ages of 18-45
  • Body mass index < 18.5 kg/m2 or >35.0 kg/m2
  • Pregnant (females only)
  • Postmenopausal status (females only).
  • Been diagnosed with a chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.)
  • Uses tobacco products or any illicit drugs.
  • Uses glucose-lowering drugs/supplements.
  • Regularly takes anti-inflammatory drugs (more than 2x week).
  • Have a pacemaker.
  • Allergic to mango, wheat, gluten, and/or milk.
  • Unable to lay in supine position in the dark for at least ten minutes.

Study Design

Enrollment

35 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Cereal Consumption with Fresh Mango

During the Cereal and Fresh Mango arm, participants will consume a bowl of corn flakes with 2% milk sweetened with fresh mango.

experimental: Cereal Consumption with Table Sugar

During the Cereal and Table Sugar arm, participants will consume a bowl of corn flakes with 2% milk sweetened with table sugar.

Interventions

High-Glycemic Breakfast Containing Cereal and Fresh Mango

High-glycemic breakfast of 84 grams of corn flakes prepared with 355 mL of 2% milk and sweetened with 262 grams of fresh mango.

High-Glycemic Breakfast Containing Cereal and Table Sugar

High-glycemic breakfast of 84 grams of corn flakes prepared with 355 mL of 2% milk and sweetened with 36 grams of table sugar.

Primary outcome measure

  • LPS [ Time Frame: Through study completion, up to 1 year. ]
  • LPS Binding Protein [ Time Frame: Through study completion, up to 1 year. ]
  • IL-6 [ Time Frame: Through study completion, up to 1 year. ]

Central Contacts and Locations

Central contacts

Bryant Keirns, PhD

765-285-8356bryant.keirns@bsu.edu

Locations

Health Professions Building, Ball State University

Recruiting

Muncie, Indiana, United States, 47306

Contacts

Bryant Keirns, PhD

765-285-8356bryant.keirns@bsu.edu

More Information

Sponsor

Ball State University

Last update posted

Jun 16, 2026

Last verified

Jun, 2026

Keywords

  • fresh mango
  • inflammation
  • intestinal permeability

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Ball State University on 2026-06-16.