Recruiting

COMPASS

Sponsor:

OHSU Knight Cancer Institute

Code:

NCT07651358

Conditions

Stage I Pancreatic Cancer AJCC v8

Stage II Pancreatic Cancer AJCC v8

Stage III Pancreatic Cancer AJCC v8

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Physical Activity and Nutritional Recommendations and Support

Study Details

Brief summary:

This clinical trial studies whether a tailored, web-based program (web portal), Community for Physical Activity and Supportive Nutrition Strategies (COMPASS), can be used to improve exercise and dietary changes in patients with stage I-III pancreatic cancer who are receiving chemotherapy before surgery (neoadjuvant). Pancreatic cancer is a rare and understudied cancer, particularly in the area of promoting a healthy lifestyle to preserve physical and mental well-being during a long and difficult treatment regimen. Since pancreatic cancer is rare, programs have limited resources available to reach the patients who could benefit from programs aimed at promoting exercise and a healthy diet. The COMPASS web-portal is easily accessed by the patient via a computer, tablet, or phone. It is tailored to the unique needs of pancreatic cancer patients and provides exercise and diet recommendations along with behavioral support as they undergo the long process of cancer therapy. This may be a more effective way to reach and engage with the patient, which may improve exercise and dietary changes in stage I-III pancreatic cancer patients receiving neoadjuvant chemotherapy.

Conditions

Stage I Pancreatic Cancer AJCC v8

Stage II Pancreatic Cancer AJCC v8

Stage III Pancreatic Cancer AJCC v8

Study ID

NCT07651358

Start date

Apr 15, 2026

Status verified date

Jun, 2026

Completion date

Jun 30, 2027

Anticipated

Primary completion date

Jan 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 years or older on date of enrollment

  • Confirmed by review of the date of birth as documented in the electronic medical record (EMR) and subsequently recorded in a case report form (CRF)
  • Diagnosed with stage I-III pancreatic cancer

  • Confirmed by EMR review. In cases where the EMR is unclear, their physician will be contacted and asked to confirm
  • Scheduled to receive neoadjuvant chemotherapy at Oregon Health \& Science University (OHSU)

  • Confirmed by EMR review. In cases where the EMR is unclear, their physician will be contacted and asked to confirm
  • Willing to adhere to the study protocol

  • Confirmed verbally with the participant and response documented in the Participant Tracking database

Exclusion Criteria:

  • Cognitive difficulties that preclude answering the survey questions, participating in the intervention, or giving informed consent

  • In the event of a suspected undeclared cognitive impairment, it will be confirmed by physician clearance or professional opinion of the Principal Investigators, Dr. Kerri Winters-Stone and/or Dr. Jackilen Shannon
  • A medical condition, movement or neurological disorder, or medication use that contraindicates participation in light intensity exercise

  • Confirmed by a combination of reviewing the EMR, and self-report during the initial screening call. If in the professional opinion of the Principal Investigator, Dr. Kerri Winters-Stone or Dr. Jackilen Shannon, contraindications other than those identified by the patient or physician are present, she may consider the participant ineligible
  • Not fluent in English and therefore incapable of answer survey questions, reading the intervention web portal, and providing informed consent in English

  • Confirmed verbally with the participant and response documented in the Participant Tracking database

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Group 1 (COMPASS + brief coaching support)

Participants receive access to COMPASS portal, a tailored exercise intervention which may consist of strength, aerobic, balance, and flexibility exercises, and tailored diet recommendations for the duration of neoadjuvant chemotherapy. Participants also receive an initial coaching call to discuss the tailored exercise intervention and dietary recommendations and may optionally receive motivational and support text messages TIW on study.

experimental: Group 2 (COMPASS + enhanced coaching support)

Participants receive the same intervention as Group 1, but receive additional monthly coaching support

Interventions

Physical Activity and Nutritional Recommendations and Support

Web-based lifestyle program that provides tailored nutrition and physical activity recommendations and web-based support strategies including text messages, electronic trackers, and coaching

Primary outcome measure

  • Accrual (Acceptability) [ Time Frame: Up to 12 months ]
  • Study retention (Acceptability) [ Time Frame: Up to 12 months ]
  • Listening session [ Time Frame: At completion of neoadjuvant chemotherapy (average of 6 months) ]
  • Exit survey [ Time Frame: At completion of neoadjuvant chemotherapy (average of 6 months) ]
  • Study intervention adherence (Feasibility) [ Time Frame: Up to 12 months ]
  • Web portal visit frequency (Feasibility) [ Time Frame: Up to 12 months ]
  • Web portal aggregate activity (Feasibility) [ Time Frame: Up to 12 months ]

Central Contacts and Locations

Locations

OHSU Knight Cancer Institute

Recruiting

Portland, Oregon, United States, 97239

Contacts

Kerri Winters-Stone

503-494-0813wintersk@ohsu.edu

Principal Investigator:

Kerri Winters-Stone

More Information

Sponsor

OHSU Knight Cancer Institute

Last update posted

Jun 16, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by OHSU Knight Cancer Institute on 2026-06-16.