Recruiting

Observational Study

Sponsor:

Cortex Neurovascular

Code:

NCT07652034

Conditions

Migraine Disorders

Chronic Migraine Headache

Migraine

Eligibility Criteria

Sex: All

Age: 18 - 64

Healthy Volunteers: Not accepted

Interventions

Middle Meningeal Artery Embolization

Study Details

Brief summary:

EMBRACE-OBS is the first phase of the EMBRACE research program. This single-site observational registry accesses and analyzes patient-reported outcome data already collected through routine clinical care from adults with migraine who have undergone or plan to undergo middle meningeal artery (MMA) embolization. The study describes changes in headache frequency, headache severity, medication use, migraine-related disability, quality of life, and reported adverse events over time without influencing clinical care.

Conditions

Migraine Disorders

Chronic Migraine Headache

Migraine

Study ID

NCT07652034

Start date

Sep 1, 2026

Status verified date

Sep, 2026

Completion date

Jun 1, 2028

Anticipated

Primary completion date

Jun 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 64

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults aged 18 to 64 years
  • Diagnosis of migraine
  • Have undergone or plan to undergo middle meningeal artery (MMA) embolization as part of routine clinical care, independent of study participation
  • Able and willing to provide informed consent
  • Able to read and understand English sufficiently to complete informed consent and patient-reported outcome assessments

Exclusion Criteria:

  • Age under 18 years
  • Pregnancy at the time of enrollment
  • Inability to provide informed consent
  • Inability to read and understand English sufficiently to complete informed consent and patient-reported outcome assessments
  • Insufficient clinical or patient-reported outcome data for the planned analyses

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Arms

Migraine Patients Undergoing MMA Embolization

Adults aged 18 to 64 years with a diagnosis of migraine who have undergone or plan to undergo middle meningeal artery (MMA) embolization as part of routine clinical care. Participants are enrolled in an observational registry that accesses and analyzes clinical and patient-reported outcome data already documented through routine care. Study participation does not influence clinical management, procedural technique, device selection, or follow-up.

Interventions

Middle Meningeal Artery Embolization

Middle meningeal artery (MMA) embolization performed as part of routine clinical care at the discretion of the treating physician. The procedure is independent of study participation and is not assigned by the study protocol. The research activity consists solely of accessing and analyzing data already documented through routine clinical care.

Primary outcome measure

  • Change in Patient-Reported Headache Frequency [ Time Frame: Baseline and 12 Months ]

Central Contacts and Locations

Central contacts

Dennis Wang, Principal Investigator, MD

253-284-0841dwang@cortexmgmt.com

Locations

Cortex Neurovascular / TRA Union

Recruiting

Tacoma, Washington, United States, 98405

Contacts

Dennis Wang, MD

253-284-0841dwang@cortexmgmt.com

dwang@cortexmgmt.com

Principal Investigator:

Dennis O Wang, MD

More Information

Sponsor

Cortex Neurovascular

Last update posted

Sep 23, 2026

Last verified

Sep, 2026

Keywords

  • Middle Meningeal Artery Embolization
  • MMA Embolization
  • Migraine
  • Headache
  • Patient-Reported Outcomes
  • HIT-6
  • Observational Registry
  • Neurointervention
  • EMBRACE-OBS

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-24. This information was provided to ClinicalTrials.gov by Cortex Neurovascular on 2026-09-23. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.