Recruiting

Exercise Program

Sponsor:

Dana-Farber Cancer Institute

Code:

NCT07662239

Conditions

Sarcoma

Bone Sarcoma

Soft Tissue Sarcoma (STS)

Eligibility Criteria

Sex: All

Age: 15 - 39

Healthy Volunteers: Not accepted

Interventions

Exercise Triage and Personalized Exercise Program

Study Details

Brief summary:

This study will evaluate strategies to improve physical function and promote exercise and physical activity in adolescents and young adults (AYAs) with sarcoma. The study will assess the feasibility of a standardized triage system for referring AYAs with sarcoma to appropriate exercise and rehabilitation services, and will also examine changes in physical function and health-related quality of life before and after a 12-week personalized exercise program.

Conditions

Sarcoma

Bone Sarcoma

Soft Tissue Sarcoma (STS)

Study ID

NCT07662239

Start date

Aug 1, 2026

Status verified date

Jun, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Aug 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 15 - 39

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosed with a bone or soft tissue sarcoma
  • Age 15-39 at time of diagnosis
  • Age 15 and older at time of enrollment
  • Age 15-17 at time of enrollment, with assent from participant and consent from parent/legal guardian
  • Established patient of the DFCI Sarcoma Center or Jimmy Fund
  • Able to read and understand English (to complete required questionnaires and participate in training/coaching)
  • Individuals who are not yet adults (teenagers) if they assent and their parents/legal guardians' consent to participation.

Exclusion Criteria:

  • Unstable cardiovascular disease in the last 6 months
  • Psychiatric disorders or conditions that would preclude participation in the study intervention (e.g. untreated major depression or psychosis, untreated substance use disorder, severe personality disorder)
  • Pregnant
  • Currently participating in physical or occupational therapy
  • Presence of medical conditions or medications that would prohibit participation in an exercise program
  • Meeting exercise guidelines of 150 minutes of moderate intensity/75 minutes of vigorous intensity physical activity per week plus consistent strength training (at least once per week) over the past 3 months. Assessed via Godin Leisure Time Questionnaire by study staff.
  • Adults unable to consent

Study Design

Enrollment

40 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Exercise Triage and Personalized Exercise Program

All participants receive this intervention.

Interventions

Exercise Triage and Personalized Exercise Program

  • Part 1: Completion of the EXCEEDS triage tool to assess physical function and determine appropriate referral to rehabilitation or exercise services.
  • Part 2: Eligible participants receive a 12-week personalized exercise program, which may be supervised or unsupervised, and includes a Garmin activity monitor, resistance bands, and a stepper machine.

Primary outcome measure

  • Triage Tool Completion Rate [ Time Frame: 2 weeks ]
  • Referral Completion Rate [ Time Frame: Within 2 months of EXCEEDS completion ]

Central Contacts and Locations

Central contacts

Chao Cao, MD

617-632-4237chao_cao@dfci.harvard.edu

Locations

Boston Children's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Chao Cao, MD

617-632-4237chao_cao@dfci.harvard.edu

Principal Investigator:

Chao Cao, MD

Brigham and Women's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Chao Cao, MD

617-632-4237chao_cao@dfci.harvard.edu

Principal Investigator:

Chao Cao, MD

Dana-Farber Cancer Institute

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Chao Cao, MD

617-632-4237chao_cao@dfci.harvard.edu

Principal Investigator:

Chao Cao, MD

More Information

Sponsor

Dana-Farber Cancer Institute

Last update posted

Aug 26, 2026

Last verified

Jun, 2026

Keywords

  • sarcoma
  • bone sarcoma
  • soft tissue sarcoma

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Dana-Farber Cancer Institute on 2026-08-26.