Recruiting

Oil Pulling

Sponsor:

The University of Texas Health Science Center at San Antonio

Code:

NCT07667088

Conditions

Healthy Adult Participants

Tooth Stain

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Not accepted

Interventions

GuruNanda natural Oil Pulling oral rinse

Therabreath Whitening Mouthwash - Dazzling Mint

GuruNanda water-based non-whitening mouthwash

Study Details

Brief summary:

The goal of this study is to evaluate the tooth whitening efficacy of Oil Pulling oral rinse compared to a competitor's whitening mouthwash and a water-based mouthwash (placebo). Each participant will use one of three mouthwashes: GuruNanda Oil Pulling oral rinse (test), Competitor's mouthwash (positive), Water-based oral rinse (placebo). All mouthwashes will be used once daily last thing before bed at night. Data will be collected on tooth shade evaluated on the anterior teeth.

Conditions

Healthy Adult Participants

Tooth Stain

Study ID

NCT07667088

Start date

May 1, 2026

Status verified date

Jun, 2026

Completion date

Aug 31, 2026

Anticipated

Primary completion date

Aug 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Adult subjects aged 18-60, that are in good health.
2. Subject must have at least 2 natural anterior teeth, each having a mean Lobene composite score of ≥ 1.5 on the facial surfaces as assessed by the Investigator.
3. Subject's front teeth shade should be 9 or darker (meaning shade score should be between 9 and 29), as assessed by the Vita bleachguide 3D-Master and the Vita EasyShade device.
4. Subjects should understand the information provided about the investigative nature of the treatment, possible benefits and side effects. Subjects will sign the Informed Consent Form.
5. The subjects should be willing to comply with the study procedure and schedule, including the follow up visits, and will refrain from using any other teeth whitening technologies during this period.
6. The subject did not perform any procedure for teeth whitening (either at home or in clinic) at least 3 years prior to participating in the study.

Exclusion Criteria:

1. Pregnant or nursing by subject report.
2. Known allergic reaction to any of the study mouthwashes or any of their components. Participant has completed the screening questionnaire (Exclusion due to Known Allergens).
3. Any active condition in the oral cavity at the discretion of the investigator.
4. Any surgery or dental procedure in the treated area within 3 months prior to treatment, or before complete healing.
5. Subjects that do not brush regularly.
6. Any condition that might make it unsafe for the subject to participate in the study, at the discretion of the investigator.
7. Heavy tobacco use, including cigarettes, cigars, or smokeless tobacco.
8. Consumption of stain-causing substances (e.g., red wine, coffee, tea) that cannot be avoided during the study period.
9. Use of medications that may affect tooth discoloration (e.g., tetracyclines, chlorhexidine).
10. Participation in another clinical trial within the last 30 days.
11. Presence of orthodontic appliances, except for removable retainers.
12. Signs of advanced enamel wear, dentin exposure, or tooth fractures.

Study Design

Enrollment

120 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Test Product

active comparator: Positive Control

placebo comparator: Negative Control

Interventions

GuruNanda natural Oil Pulling oral rinse

Test product

Therabreath Whitening Mouthwash - Dazzling Mint

positive control

GuruNanda water-based non-whitening mouthwash

negative control

Primary outcome measure

  • Measurement by the VITA Easyshade Advance 4.0 [ Time Frame: Baseline to 8 weeks ]
  • VITA Bleachguide 3-D Master Shade Guide [ Time Frame: Baseline to 8 weeks ]
  • Lobene Stain Index [ Time Frame: Baseline to 8 weeks ]

Central Contacts and Locations

Central contacts

Bennett T Amaechi, BDS, MS, PhD, MFDS RCPS, FADI

210-567-3185amaechi@uthscsa.edu

Locations

Clinical Research Facility of the Center for Oral Health and Research, UTHSA

Recruiting

San Antonio, Texas, United States, 78229

Contacts

Bennett T Amaechi, BDS, MS, PhD, MFDS RCPS, FADI

210-567-3185amaechi@uthscsa.edu

More Information

Sponsor

The University of Texas Health Science Center at San Antonio

Last update posted

Jun 24, 2026

Last verified

Jun, 2026

Keywords

  • tooth whitening
  • tooth stains
  • oil pulling
  • mouthwash
  • mouth rinse
  • stain removal

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by The University of Texas Health Science Center at San Antonio on 2026-06-24.