Recruiting

BrocElite & Treadmill

Sponsor:

University of British Columbia

Code:

NCT07668596

Conditions

Immunometabolism

Mitochondrial Function, Bioenergetics

Inflammation

Eligibility Criteria

Sex: All

Age: 19 - 35

Healthy Volunteers: Accepted

Interventions

Sulforaphane-rich Broccoli Sprout Extract

High Intensity Interval Treadmill Running

Study Details

Brief summary:

The study consist of 3 interventional periods which will be completed by each consenting participant in a randomized, crossover fashion. The interventional periods will be separated by a minimum 1 week washout period. One of the interventions consists of 4 days of daily supplementation with the commercially available broccoli sprout extract capsules (BrocElite). Another intervention will consist of 4 days of daily supervised treadmill running. The exercise protocol consists of 4 minutes of high-intensity running running followed by a 3 minute recovery period, repeated for a total of 4 repetitions. The last intervention combines the above two and consists of 4 days of daily supplementation and daily supervised exercise training. Before and after each intervention, basic anthropometrics (weight, heart rate, and blood pressure) will be recorded, and a venous blood sample will be collected. Blood samples will be analyzed for metabolic and inflammatory markers. Participants will be asked to refrain from structured exercise, alcohol consumption, and broccoli consumption during each of the experimental periods. Before any testing, willing participants will provide informed consent, and fill out a few demographic, and lifestyle questionnaires. The study will be conducted at the University of British Columbia in Kelowna, BC, Canada.

Conditions

Immunometabolism

Mitochondrial Function, Bioenergetics

Inflammation

Study ID

NCT07668596

Start date

Mar 1, 2026

Status verified date

Jul, 2026

Completion date

Jun 1, 2028

Anticipated

Primary completion date

Dec 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19 - 35

Healthy Volunteers: Accepted

Inclusion Criteria:

  • aged between 19 and 35 years
  • not a current smoker
  • physically active based on the Canadian Physical Activity Guidelines (150 minutes of weekly physical activity)

Exclusion Criteria:

  • a history of cardiometabolic diseases or respiratory diseases (e.g., chronic obstructive pulmonary disease, asthma, diabetes, coronary artery disease)
  • currently following a ketogenic diet
  • body mass index (BMI) over 30 kg/m2
  • unable to read or communicate in English
  • having received a vaccination or experienced an upper respiratory tract infection in the last 4 weeks
  • having donated more than 0.5 L of blood within the last 4 weeks
  • currently pregnant
  • have contraindications to high intensity exercise (assessed using the CSEP Get Active Questionnaire)

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Sulforaphane Supplementation Only

In this intervention, participants will consume commercially available broccoli sprout extract capsules daily for 4 days (20 mg/day) . Basic anthropometrics (weight, heart rate, blood pressure) and a venous blood sample (30 mL) will be collected before and after this interventional period.

active comparator: Exercise Only

In this intervention, participants will complete supervised exercise sessions daily for 4 days. The exercise intervention consists of interval running on a treadmill which contains 4 cycles of: 4 minutes of intense running (85-95% HRmax) followed by 3 minutes at a slow, easy pace. Basic anthropometrics (weight, heart rate, blood pressure) and a venous blood sample (30 mL) will be collected before and after this interventional period.

experimental: Sulforaphane Supplementation and Exercise

In this intervention, participants will consume commercially available broccoli sprout extract tablets daily for 4 days. In addition, participants will complete supervised exercise sessions daily for 4 days. The exercise intervention consists of interval running on a treadmill which contains 4 cycles of: 4 minutes of intense running (85-95% HRmax) followed by 3 minutes at a slow, easy pace. Basic anthropometrics (weight, heart rate, blood pressure) and a venous blood sample (30 mL) will be collected before and after this interventional period.

Interventions

Sulforaphane-rich Broccoli Sprout Extract

Broc Elite Plus stabilized sulforaphane capsules from Mara Labs

High Intensity Interval Treadmill Running

4 cycles of: 4 minutes of intense treadmill running (85-95% HR max) followed by 3 minutes of slow, easy running.

Primary outcome measure

  • Change in peripheral blood mononuclear cell oxygen consumption rate [ Time Frame: 0-4 days ]

Central Contacts and Locations

Central contacts

Hashim Islam Principle Investigator, Ph.D

250-807-9122hashim.islam@ubc.ca

Locations

Reichwald Health Sciences Centre

Recruiting

Kelowna, British Columbia, Canada, V1V 1V7

Contacts

Sean McIntyre

2505757528smcint04@student.ubc.ca

More Information

Sponsor

University of British Columbia

Last update posted

Jul 17, 2026

Last verified

Jul, 2026

Keywords

  • Nutraceuticals
  • Exercise
  • Bioenergetics
  • Immunometabolism
  • Inflammation
  • High intensity interval training

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of British Columbia on 2026-07-17.