Recruiting

Preventive Health Screening

Sponsor:

William Brandenburg, MD

Code:

NCT07669168

Conditions

Health Services Accessibility

Rural Health

Medically Underserved Area

Preventive Health Services

Patient Participation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

AI-Assisted Screening Interpretation (AI Reads)

Human-Only Screening Interpretation

Study Details

Brief summary:

The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening system deployable in any environment, including the most isolated and resource-limited communities. Each change is isolated as a single variable against current practice, and every comparison is evaluated with a common set of engagement, behavior-change, experience, cost, and longitudinal outcome measures, so results accumulate on a consistent yardstick across the life of the platform.

The first comparison evaluates AI-assisted versus human-only interpretation ("reads") of screening data. Subsequent pre-planned comparisons, added by protocol amendment, evaluate static versus interactive personalized report delivery; mobile community versus fixed laboratory screening; and a hybrid medical-droid-plus-human delivery model versus human-only screening.

Conditions

Health Services Accessibility

Rural Health

Medically Underserved Area

Preventive Health Services

Patient Participation

Study ID

NCT07669168

Start date

Jun 9, 2026

Status verified date

Sep, 2026

Completion date

Dec 31, 2099

Anticipated

Primary completion date

Dec 31, 2099

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age 18 years or older
  • Willing and able to provide written informed consent, or enrollment with consent of a legally authorized representative
  • Willing to participate in longitudinal follow-up.

Exclusion Criteria:

\- Age under 18 years.

Study Design

Enrollment

1000000 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

active comparator: Human-Only Screening Interpretation

Participants receive comprehensive preventive health screening under the standard of care for the comparison in progress. In the active comparison, all screening data, images, tracings, and laboratory results are interpreted by the physician of record and qualified clinical staff under physician supervision, without AI decision support.

experimental: AI-Assisted Screening Interpretation (AI Reads)

Participants receive identical screening with one element modified: the single variable under test in the comparison in progress. In the active comparison, models produce AI-generated reads of the acquired data, presented to the physician of record as a clinical aid. The physician reviews each read, records a structured judgment before sign-off, and produces and signs the released interpretation. The comparison runs in two screening-complexity strata, with a single general model in the simple stratum and a general model plus at least three domain-specific models in the comprehensive stratum.

Interventions

AI-Assisted Screening Interpretation (AI Reads)

An AI-generated read of the acquired screening battery is produced and presented to the physician of record as a clinical aid. All models used are third-party models, executed unmodified on Longevity Metrics clinical infrastructure. The physician reviews each read, records a structured judgment before sign-off, and then produces and signs the released interpretation, which may adopt, modify, or reject any read.

Human-Only Screening Interpretation

All acquired screening data, images, tracings, and laboratory results are interpreted by the physician of record and qualified clinical staff under physician supervision, by standard practice and without AI decision support. This is the current standard of care and the active comparator.

Primary outcome measure

  • Health Awareness and Action (Non-Inferiority) [ Time Frame: Baseline (intake, completed at home before the screening visit); 1-2 weeks after screening, at report delivery; 6-12-month follow-up; then periodically from enrollment until death, up to 100 years. ]

Central Contacts and Locations

Central contacts

William Brandenburg, MD

13035010016info@longevitymetrics.org

Locations

Longevity Metrics

Recruiting

Boulder, Colorado, United States, 80301

Contacts

William Brandenburg, MD

3035010016info@longevitymetrics.org

More Information

Sponsor

William Brandenburg, MD

Last update posted

Sep 8, 2026

Last verified

Sep, 2026

Keywords

  • Sequential Platform Trial
  • Interactive Health Report
  • Health Activation
  • Mobile Health Screening
  • Comparative Effectiveness
  • Health Equity
  • Rural Health
  • Medically Underserved
  • Preventive Medicine
  • Patient Engagement
  • Cardiopulmonary Exercise Testing
  • Body Composition
  • DEXA
  • Health Ahead Bus
  • Mobile Clinic
  • Automated Screening
  • Medical Droids
  • Biological Age
  • Healthspan
  • Longevity
  • Life Expectancy
  • Chronic Disease
  • Cost-Effectiveness
  • Health Services Research
  • Artificial Intelligence
  • Clinical Decision Support
  • Diagnostic Interpretation
  • Machine Learning

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by William Brandenburg, MD on 2026-09-08.