Recruiting

nCPAP

Sponsor:

University of Arkansas

Code:

NCT07674953

Conditions

Respiratory Distress Syndrome (Neonatal)

Respiratory Distress of Newborn

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Effective oxygen delivery and lung expansion measurement

Study Details

Brief summary:

With this study, it is expected to learn more about preterm babies on breathing support with nasal continuous positive airway pressure (nCPAP). To gain more information on how much oxygen is actually delivered to the baby from the nCPAP machine.

Conditions

Respiratory Distress Syndrome (Neonatal)

Respiratory Distress of Newborn

Study ID

NCT07674953

Start date

Apr 15, 2026

Status verified date

Jun, 2026

Completion date

Jun, 2027

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Gestational age at birth must be less than 35 weeks of completed gestation as documented in the subject's initial history and physical
  • The infant must be stable while receiving nasal CPAP at any pressure level at the time of study
  • The infant must be receiving 22-40% at the time of the study

Exclusion Criteria:

  • Oxygen requirements greater than 40% at time of enrollment
  • currently receiving invasive ventilation or not requiring ventilatory support
  • Major congenital anomalies of the heart and/or lungs

Study Design

Enrollment

10 participants

Anticipated

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Infants on nCPAP

All infants on CPAP will have a catheter placed in their oropharynx to measure delivered oxygen and a soft band placed around the infant's chest to measure lung expansion.

Interventions

Effective oxygen delivery and lung expansion measurement

This intervention arm will involve any infant who is already on nCPAP. It will involve placing a catheter in the infant's oropharynx and wrapping soft EIT bands around the infants chest to measure effective oxygen delivery and lung expansion, respectively.

Primary outcome measure

  • Inspired Oxygen [ Time Frame: Sampling will occur at three separate points within a thirty minute time frame for each enrolled infant. ]

Central Contacts and Locations

Central contacts

Nicholas A Rowley, MD

940-230-5002NARowley@uams.edu

Locations

University of Arkansas for Medical Sciences

Recruiting

Little Rock, Arkansas, United States, 72205

Contacts

Sherry Courtney Research Mentor, MD

501-526-1500SECourtney@uams.edu

Principal Investigator:

Nicholas Rowley, MD

More Information

Sponsor

University of Arkansas

Last update posted

Jun 30, 2026

Last verified

Jun, 2026

Keywords

  • respiratory distress syndrome
  • CPAP
  • preterm infant
  • effective oxygen delivery

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Arkansas on 2026-06-30.