Recruiting

Blood Flow Restriction

Sponsor:

University of British Columbia

Code:

NCT07676305

Conditions

Type 2 Diabetes

Eligibility Criteria

Sex: All

Age: 19 - 64

Healthy Volunteers: Not accepted

Interventions

Exercise

Study Details

Brief summary:

To conduct a randomized control trial to determine the impact of 6-weeks of blood flow restriction training on immune cell function and bioenergetics in adults living with type 2 diabetes.

Conditions

Type 2 Diabetes

Study ID

NCT07676305

Start date

Feb 11, 2026

Status verified date

Jun, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19 - 64

Healthy Volunteers: Not accepted

Inclusion Criteria:

A. Aged 19-64 years. B. Diagnosed with type 2 diabetes with current HbA1c 5.7-9.0% C. Completing <150 minutes of moderate-vigorous physical activity per week.

Exclusion Criteria:

A. Chronic musculoskeletal condition or recent (within 2 years) cardiovascular event preventing participation in exercise.

B. Unstable type 2 diabetes medication of the last 3 months C. Absolute contraindications to BFR (i.e., peripheral vascular disease) D. A self-reported diagnosis of low iron concentrations, anemia, or being treated for these conditions E. A diagnosis of any red blood cell-altering condition (i.e., sickle cell anemia, poikilocytosis) F. Currently living with any cardiovascular disease, which would impact the ability to participate in exercise safely G. Currently prescribed any medication which would impact the ability to use a heart rate monitor to accurately track intensity

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Treadmill walking with blood flow restriction

Treadmill walking with blood flow restriction performed 3 days per week for 6 weeks.

active comparator: Treadmill Walking

Treadmill walking performed 3 days per week for 6 weeks.

Interventions

Exercise

In both groups participants will complete treadmill walking on 3 days per week for 6 weeks. During the first week participants will walk continuously for 21 minutes during each training session which will be increased to 32 minutes per training session for weeks 2-6. In both groups the treadmill speed and grade will be set to elicit 40-50% heart rate reserve. In the BFR group the cuffs will be inflated based on each participants individualized limb occlusion pressure (LOP). The cuffs will remain inflated for the entire session but will deflate for 1 min every 10 min based on safety recommendations. The percentage of LOP will progressively increase over the course of the intervention. Weeks 1 and 2 will be completed at 60% LOP, after which pressure will increase by 5% each subsequent week, corresponding to 65%, 70%, 75%, and 80% LOP during weeks 3, 4, 5, and 6, respectively.

Primary outcome measure

  • Change in T-cell oxygen consumption rate (OCR) measured before and after the 6-week intervention [ Time Frame: 0-6 weeks ]

Central Contacts and Locations

Central contacts

Jonathan P Little, PhD

250-807-9876jonathan.little@ubc.ca

Locations

University of British Columbia Okanagan

Recruiting

Kelowna, British Columbia, Canada, V1V 1V7

Contacts

Jonathan P Little, PhD

250-807-9876jonathan.little@ubc.ca

More Information

Sponsor

University of British Columbia

Last update posted

Jun 30, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of British Columbia on 2026-06-30.