Recruiting

Olfactory Training

Sponsor:

The Cleveland Clinic

Code:

NCT07681973

Conditions

Smell Loss

Chronic Rhinosinusitis (CRS)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Smell Training

Study Details

Brief summary:

A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss. The impact of a 3-month olfactory training program on smell function, immunological changes, and mental health in patients with smell loss will be evaluated.

The primary purpose of this study is to investigate tissue and blood samples to identify molecules that may be related to smell loss, ultimately aiming to develop future treatments for this condition and correlate with cognition.

Conditions

Smell Loss

Chronic Rhinosinusitis (CRS)

Study ID

NCT07681973

Start date

Dec 9, 2025

Status verified date

Jun, 2026

Completion date

Mar 31, 2027

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age less than 18 years-old
  • Present to rhinology clinic with CRS with nasal polyps
  • Sense of smell loss for any reason (other than trauma or tumor)

Exclusion Criteria:

  • Patients < 18 years of age
  • Individuals with unilateral nasal polyps
  • Autoimmune diseases
  • Ciliary disorders
  • Cystic fibrosis
  • Smell loss due to tumors or trauma

Study Design

Enrollment

52 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

active comparator: Group 1: - loss of smell + CRS with nasal polyps (CRSwNP)

Loss of smell + CRS with nasal polyps (CRSwNP)

active comparator: Group 2: - loss of smell with no CRS/no polyps - undergo 3 months of smell training

Loss of smell + CRS with nasal polyps (CRSwNP) - undergo 3 months of smell training

no intervention: Control Group 1: - no loss of smell CRS with nasal polyps (CRSwNP)

No loss of smell CRS with nasal polyps (CRSwNP)

no intervention: Control Group 2: -no loss of smell / no CRS/no polyps

No loss of smell / no CRS/no polyps

Interventions

Smell Training

Patients experiencing loss of smell from chronic rhinosinusitis (CRS)will undergo smell training.

Primary outcome measure

  • Primary Outcome Measure 1: Baseline olfactory function measured by UPSIT score [ Time Frame: Baseline ]
  • Primary Outcome Measure 2: Baseline quality-of-life impact of olfactory dysfunction measured by QOD-NS score [ Time Frame: Baseline ]
  • Primary Outcome Measure 3: Baseline cognitive function measured by MMSE score [ Time Frame: Baseline ]
  • Primary Outcome Measure 4: Baseline nasal cytokine concentration [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

John O'Neill

4405062611ONEILLJ2@ccf.org

Christopher Novicky

216-444-7018novickc@ccf.org

Locations

The Cleveland Clinic

Recruiting

Cleveland, Ohio, United States, 44195

Contacts

John O'Neill

4405062611ONEILLJ2@ccf.org

Hana Rosen

216-444-7018rosenh@ccf.org

Principal Investigator:

Mohamad Chaaban

More Information

Sponsor

The Cleveland Clinic

Last update posted

Jul 2, 2026

Last verified

Jun, 2026

Keywords

  • Smell Loss
  • Chronic Rhinosinusitis
  • Nasal Polyps
  • CRSwNP

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by The Cleveland Clinic on 2026-07-02.