Recruiting

Biograph Vision Quadra

Sponsor:

Memorial Sloan Kettering Cancer Center

Code:

NCT07690917

Conditions

Non Small Cell Lung Carcinoma NSCLC

Head and Neck Cancer

Prostate Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Biograph Vision Quadra scanner

PET/CT

Study Details

Brief summary:

The researchers are doing this study to test the capabilities of a new total-body PET scanner called the Biograph Vision Quadra. The researchers want to learn whether this scanner can produce better PET/CT images and provide more useful imaging information than standard PET/CT scanners.

Conditions

Non Small Cell Lung Carcinoma NSCLC

Head and Neck Cancer

Prostate Cancer

Study ID

NCT07690917

Start date

Jun 30, 2026

Status verified date

Jul, 2026

Completion date

Jun, 2029

Anticipated

Primary completion date

Jun, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Eligibility Criteria for objective #1:

  • Patients with histologically-confirmed non-small cell lung carcinoma (NSCLC) with a single or multiple lung nodules.
  • Patients who are undergoing a planned PET-CT scan at main campus of MSK.
  • Patients must be ≥ 18 years old

Eligibility Criteria for objective #2:

  • Patients with disease within the chest, abdomen or pelvis, who could benefit from visualizing the pharmacokinetics of radiotracer uptake within all disease sites simultaneously.
  • Patients with metastatic prostate or head and neck cancer.
  • Patients with prostate cancer who are undergoing a 68Ga-PSMA or 18F-FDG scan at the main campus of MSK.
  • Patients with head and neck cancer who are undergoing a 18F-FDG scan at the main campus of MSK
  • Patients must be ≥ 18 years old

Eligibility Criteria for objective #3:

  • Patients with histologically-confirmed cancer from all three groups (lung cancer, head and neck cancer, prostate cancer).
  • Patients who are undergoing an 68Ga-PSMA or 18F-FDG or an \[18F\]-fluormisonidazole PET-CT scan at the main campus of MSK.
  • Patients willing to return to the MITS clinc for late imaging session between 2 to 6 hours after the PET radiotracer injection. (In current practice, FDG is imaged between 1 and 1.5 hours post injection, and FMISO is imaged between 2.5 and 3 hours post injection)
  • Patients must be ≥ 18 years old

Exclusion Criteria:

  • Patients who suffer from claustrophobia.
  • Women who are pregnant or breast-feeding.
  • Patients < 18 years of age

Study Design

Enrollment

90 participants

Anticipated

Interventions and Outcome Measures

Arms

Patients with lung, head and neck, and prostate cancer

The only investigational aspect of this quality improvement protocol is the acquisition of additional PET/CT imaging data (e.g. breath-hold, dynamic, and/or delayed acquisition) in patients who are already scheduled to receive a PET/CT scan as part of standard of care or under an existing clinical trial.

Interventions

Biograph Vision Quadra scanner

new total-body PET scanner, 1 or 2 additional scans with the Biograph Vision Quadra scanner.

PET/CT

Scheduled PET/CT scan

Primary outcome measure

  • image quality [ Time Frame: 3 years ]

Central Contacts and Locations

Central contacts

Heiko Schoder, MD

212-639-8001schoderh@mskcc.org

John Humm, PhD

212-639-7367

Locations

Memorial Sloan Kettering Basking Ridge (Consent Only)

Recruiting

Basking Ridge, New Jersey, United States, 07920

Contacts

Heiko Schoder, MD

212-639-8001

Memorial Sloan Kettering Monmouth (Consent Only)

Recruiting

Middletown, New Jersey, United States, 07748

Contacts

Heiko Schoder, MD

212-639-8001

Memorial Sloan Kettering Bergen (Consent Only )

Recruiting

Montvale, New Jersey, United States, 07645

Contacts

Heiko Schoder, MD

212-639-8001

Memorial Sloan Kettering Suffolk-Commack (Consent Only)

Recruiting

Commack, New York, United States, 11725

Contacts

Heiko Schoder, MD

212-639-8001

Memorial Sloan Kettering Westchester (Consent Only)

Recruiting

Harrison, New York, United States, 10604

Contacts

Heiko Schoder, MD

212-639-8001

Memorial Sloan Kettering Cancer Center

Recruiting

New York, New York, United States, 10065

Contacts

Heiko Schoder, MD

212-639-8001

Memorial Sloan Kettering Nassau (Consent Only)

Recruiting

Rockville Centre, New York, United States, 11553

Contacts

Heiko Schoder, MD

212-639-8001

More Information

Sponsor

Memorial Sloan Kettering Cancer Center

Last update posted

Jul 8, 2026

Last verified

Jul, 2026

Keywords

  • Whole body PET scanner
  • 26-227

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center on 2026-07-08.