Recruiting

Exercise Regimens

Sponsor:

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Code:

NCT07698314

Conditions

Cancer

Breast Cancer

Eligibility Criteria

Sex: Female

Age: 20 - 70+

Healthy Volunteers: Not accepted

Interventions

Conditioning Resistance Training

Strength Resistance Training

Hypertrophy Resistance Training

Study Details

Brief summary:

In this pilot study, the investigators will assess the changes in myokine production based on several different exercise regimens.

Conditions

Cancer

Breast Cancer

Study ID

NCT07698314

Start date

Jul 6, 2026

Status verified date

Sep, 2026

Completion date

Jul, 2028

Anticipated

Primary completion date

Jul, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 20 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Age 20-89 years
2. Women prescribed exercise as a SOC
3. Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast
4. Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed.
5. Women with > 3 months of resistance training experience under expert guidance at the Allegheny Health Network Exercise Oncology Center

Exclusion Criteria:

1. Any current treatment with cytotoxic chemotherapy for breast cancer
2. Inability to safely engage in group sessions of resistance training as deemed by study PI
3. Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by PI to be unsafe to engage in resistance training
4. Pregnant women
5. Males

Study Design

Enrollment

21 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Conditioning Regimen Group

experimental: Strength Regimen Group

experimental: Hypertrophy Regimen Group

Interventions

Conditioning Resistance Training

Participants in this group will perform a conditioning regimen from the EXERT-BCHC protocol, specifically described as "double training".

Strength Resistance Training

Participants in this group will perform a strength regimen from the EXERT-BCHC protocol, specifically described as "8x8".

Hypertrophy Resistance Training

Participants in this group will perform a hypertrophy regimen from the EXERT-BCHC protocol, specifically described as the "control arm".

Primary outcome measure

  • Change in Myokine Production After First Exercise Session [ Time Frame: Immediately before and immediately after the first exercise session. ]
  • Change in Myokine Production After Final Exercise Session of Each Week [ Time Frame: Immediately before and immediately after the final exercise session of weeks 1, 2, 3, and 4. ]
  • Change in Myokine Production After Final Exercise Session of the Month (End of Study) [ Time Frame: Immediately before and immediately after the final exercise session of week 4 (end of the 4-week exercise regimen). ]

Central Contacts and Locations

Central contacts

Clinical Trials Contact

412-330-6151ctgov@ahn.org

Locations

Allegheny General Hospital

Recruiting

Pittsburgh, Pennsylvania, United States, 15212

Contacts

Clinical Trials Contact

4123306151ctgov@ahn.org

More Information

Sponsor

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Last update posted

Sep 30, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-01. This information was provided to ClinicalTrials.gov by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) on 2026-09-30. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.