Recruiting

Observational Study

Sponsor:

Memorial Sloan Kettering Cancer Center

Code:

NCT07701733

Conditions

Lung Cancer

Eligibility Criteria

Sex: All

Age: 40 - 70+

Healthy Volunteers: Accepted

Interventions

Questionnaire

Study Details

Brief summary:

The researchers are doing this study to learn more about factors that may increase the risk of lung cancer in people who have never smoked. This information may help predict which people who have never smoked may be more likely to get lung cancer.

Conditions

Lung Cancer

Study ID

NCT07701733

Start date

Jun 30, 2026

Status verified date

Aug, 2026

Completion date

Jun, 2029

Anticipated

Primary completion date

Jun, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40 - 70+

Healthy Volunteers: Accepted

Criteria:

  • Female at birth
  • Age 40-74 years
  • No smoking history

  • Participants must be never-smokers, defined as having smoked <100 cigarettes in their lifetime
  • Documentation of disease - case patients

o Case patients must have pathologically confirmed primary lung adenocarcinoma. New and prevalent cases will be eligible. Case patients with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment.
  • Criteria for control participants

  • Control participants must have no personal history of lung cancer, symptoms suspicious for lung cancer, or suspicious pulmonary nodules. Participants recruited as controls and found on imaging to have lesions suspicious for lung cancer will be excluded from analysis and followed prospectively. Data regarding these participants will be reported in a sensitivity analysis. Additional control participants will be recruited to ensure balanced age- and race-matched enrollment by frequency matching. Control participants with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment.

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Arms

Case patients

Must have pathologically confirmed primary lung adenocarcinoma.

Control participants

Must have no personal history of lung cancer, symptoms suspicious for lung cancer, or suspicious pulmonary nodules.

Interventions

Questionnaire

The study questionnaire will be administered at a regular treatment visit for case patients and at a study-specific visit for control participants. At the same visit, 1 vial of blood will be collected for genomic analysis for research purposes from both case patients and control participants. Collection of demographic information and exposure data.

Primary outcome measure

  • Identify factors associated with the risk of NSCLC [ Time Frame: 3 years ]

Central Contacts and Locations

Central contacts

Alexis Chidi, MD, PhD

(929) 829-0677arisestudy@mskcc.org

Tafadzwa Chaunzwa, MD

(929) 829-0677

Locations

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)

Recruiting

Basking Ridge, New Jersey, United States, 07920

Contacts

Alexis Chidi, MD, PhD

929-829-0677

Memorial Sloan Kettering Monmouth (All Protocol Activities)

Recruiting

Middletown, New Jersey, United States, 07748

Contacts

Alexis Chidi, MD, PhD

929-829-0677

Memorial Sloan Kettering Bergen (All Protocol Activities)

Recruiting

Montvale, New Jersey, United States, 07645

Contacts

Alexis Chidi, MD, PhD

929-829-0677

Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)

Recruiting

Commack, New York, United States, 11725

Contacts

Alexis Chidi, MD, PhD

929-829-0677

Memorial Sloan Kettering Westchester (All Protocol Activities)

Recruiting

Harrison, New York, United States, 10604

Contacts

Alexis Chidi, MD, PhD

929-829-0677

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

Recruiting

New York, New York, United States, 10065

Contacts

Alexis Chidi, MD, PhD

929-829-0677

Memorial Sloan Kettering Nassau (All Protocol Activities)

Recruiting

Uniondale, New York, United States, 11553

Contacts

Alexis Chidi, MD, PhD

929-829-0677

More Information

Sponsor

Memorial Sloan Kettering Cancer Center

Last update posted

Aug 14, 2026

Last verified

Aug, 2026

Keywords

  • 26-239

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center on 2026-08-14.