Recruiting

Oxygen Prebreathe

Sponsor:

Duke University

Code:

NCT07702539

Conditions

Decompression Sickness

Eligibility Criteria

Sex: All

Age: 30 - 60

Healthy Volunteers: Accepted

Interventions

Oxygen Prebreathe and Hypobaric Exposure

Study Details

Brief summary:

This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.

Conditions

Decompression Sickness

Study ID

NCT07702539

Start date

Aug 13, 2026

Status verified date

Sep, 2026

Completion date

Feb 27, 2027

Anticipated

Primary completion date

Feb 27, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 30 - 60

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Non-smoking volunteers aged 30-60 years
  • Able to meet VO2 peak requirements (>35 ml/kg/min males, >30 ml/kg/min females)

Exclusion Criteria:

  • Pregnancy
  • Lung disease, heart disease, hypertension, or diabetes
  • Musculoskeletal pain conditions
  • Requirement for regular medications such as analgesics

Study Design

Enrollment

30 participants

Anticipated

Intervention Model

Single group

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Single Arm

Participants undergo oxygen prebreathe followed by hypobaric chamber exposure with exercise and monitoring.

Interventions

Oxygen Prebreathe and Hypobaric Exposure

Prebreathe 100% oxygen followed by simulated spacewalk conditions in hypobaric chamber with exercise protocols.

Primary outcome measure

  • Number of participants with Decompression Sickness [ Time Frame: Up to 6 months ]

Central Contacts and Locations

Locations

Duke University Medical Center

Recruiting

Durham, North Carolina, United States, 27710

Contacts

Richard E Moon, MD

919-684-6726richard.moon@duke.edu

Zach Ransom

919-684-6726zach.ransom@duke.edu

More Information

Sponsor

Duke University

Last update posted

Sep 22, 2026

Last verified

Sep, 2026

Keywords

  • Decompression Sickness
  • Prebreathe Oxygen
  • Hypobaric Exposure

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-24. This information was provided to ClinicalTrials.gov by Duke University on 2026-09-22. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.