Recruiting

Oil Pulling

Sponsor:

The University of Texas Health Science Center at San Antonio

Code:

NCT07706647

Conditions

Good Health

Gingival Inflammation and Bleeding

Dental Plaque

Eligibility Criteria

Sex: All

Age: 18 - 70

Healthy Volunteers: Not accepted

Interventions

GuruNanda natural Oil Pulling oral rinse

TheraBreath Plaque Control Oral Rinse

GuruNanda water-based non-whitening mouthwash

Study Details

Brief summary:

The goal of this study is to scientifically evaluate the efficacy of this oil pulling oral rinse in reducing dental plaque, gingival inflammation, gingival bleeding, and selectively reducing caries- and periodontal disease-associated bacteria compared to a marketed mouthwash and a placebo oral rinse

Conditions

Good Health

Gingival Inflammation and Bleeding

Dental Plaque

Study ID

NCT07706647

Start date

Jul 8, 2026

Status verified date

Aug, 2026

Completion date

Nov 30, 2026

Anticipated

Primary completion date

Nov 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Adult subjects aged 18-70, that are in good health.
2. Subject must have:

1. Baseline gingival inflammation (MGI) score of at least 1.80.
2. Baseline gingival bleeding (GBI) score of ≥ 1 on at least 20 sites.
3. An overnight (12 to 18 hour abstention from any oral hygiene) dental plaque (mean) score greater than 0.6 according to the RMNPI Index.
4. Have a minimum of 20 'scorable' teeth (excluding 3rd molars).
5. The subjects should understand the information provided about the investigative nature of the treatment, possible benefits and side effects. Subjects will sign the Informed Consent Form.
6. The subjects should be willing to comply with the study procedure and schedule, including the follow-up visits.

Exclusion Criteria:

1. Current or history of oral cavity cancer or oropharyngeal cancer.
2. Subject with destructive periodontal disease or those on antibiotic or anti-inflammatory drugs.
3. Pacemaker or internal defibrillator, or any other active electrical implant anywhere in the body.
4. Pregnant or nursing by subject report.
5. Known allergic reaction to any of the study mouthwashes or any of their component.
6. Any active condition, including but not limited to advanced periodontal disease or severe gingival recession, in the oral cavity at the discretion of the investigator.
7. Any surgery or recent dental procedure in the oral cavity within 3 months prior to treatment, or before complete healing.
8. Subjects that do not brush regularly.
9. Any condition that might make it unsafe for the subject to participate in this study, at the discretion of the investigator.
10. History of allergy or hypersensitivity to mouthwash ingredients
11. Significant medical conditions, such as uncontrolled diabetes or immunosuppressive disorders
12. Use of tobacco products, including cigarettes and smokeless tobacco
13. Presence of orthodontic appliances, except for removable retainers
14. Participation in another clinical trial within the last 30 days.
15. Individuals unable to comply with study requirements, such as regular product use or scheduled visits.
16. Habitual use of alcohol or drugs that may affect compliance or oral health

Study Design

Enrollment

120 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Test Product

active comparator: Positive Control

placebo comparator: Negative Control

Negative Control

Interventions

GuruNanda natural Oil Pulling oral rinse

test product

TheraBreath Plaque Control Oral Rinse

negative control

GuruNanda water-based non-whitening mouthwash

negative control

Primary outcome measure

  • Modified Gingival Index (MGI) [ Time Frame: Baseline to 8 weeks ]
  • Gingival Bleeding Index (GBI) [ Time Frame: Baseline to 8 weeks ]
  • Rustogi Modified Navy Plaque Index (RMNPI) [ Time Frame: Baseline to 8 weeks ]
  • Measurement of plaque microbiome analysis [ Time Frame: Baseline to 8 weeks ]

Central Contacts and Locations

Central contacts

Bennett T Amaechi, BDS, MS, PhD

210-567-3185amaechi@uthscsa.edu

Locations

Clinical Research Facility of the Center for Oral Health and Research, UTHSA

Recruiting

San Antonio, Texas, United States, 78229

Contacts

More Information

Sponsor

The University of Texas Health Science Center at San Antonio

Last update posted

Aug 24, 2026

Last verified

Aug, 2026

Keywords

  • mouthwash
  • gingivitis
  • plaque
  • dental

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by The University of Texas Health Science Center at San Antonio on 2026-08-24.