Recruiting

ACT+MBRP

Sponsor:

University of New Mexico

Code:

NCT07711795

Conditions

Opioid Use Disorder (OUD)

Chronic Pain

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Mindfulness text messages

Study Details

Brief summary:

The goal of this clinical trial is to examine the effects of reminder and mindfulness text messages based on integrated Acceptance and Commitment Therapy and Mindfulness Based Relapse Prevention (ACT+MBRP) on medication adherence and managing craving, pain, mindfulness, and withdrawal symptoms in people taking medications for opioid use disorder and with chronic pain through assessment questions collected six times daily during the course of treatment. The main questions it aims to answer are:

1. Do daily medication reminder text messages increase medication adherence for people taking medications for opioid use disorder?
2. To what extent do people engage with the daily mindfulness messages?
3. Do participants receiving a structured curriculum of mindfulness messages delivered twice daily differ from those receiving randomly selected mindfulness messages delivered four times daily in engagement with the intervention?
4. How do the two mindfulness text messaging interventions differ in their effects on intervention engagement, craving, pain, mindfulness, and withdrawal symptoms?

Participants will:

1. Receive daily medication reminder text messages for 12 weeks (i.e., 3 months)
2. Receive either 2 or 4 mindfulness messages per day for 6 weeks
3. Answer brief assessment questions six times per day during the 6-week mindfulness text messaging period
4. Complete questionnaires at enrollment (baseline), once each week during the 6-week mindfulness text messaging period (6 total), immediately after the 6-week mindfulness text messaging period (post-treatment), and 6 weeks after the mindfulness text messaging period ends (follow-up)

Conditions

Opioid Use Disorder (OUD)

Chronic Pain

Study ID

NCT07711795

Start date

Apr 23, 2025

Status verified date

Jul, 2026

Completion date

Oct, 2027

Anticipated

Primary completion date

Jul, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 years or older
  • Reside in the United States
  • Own or have access to a mobile phone capable of sending and receiving text messages
  • Have reliable internet access to complete study surveys
  • Be willing and able to comply with all study procedures and remain available for the duration of the study
  • Be interested in receiving medication reminders and mindfulness text messages
  • Be within 2 months of initiating or restarting methadone or buprenorphine treatment for opioid use
  • Report chronic pain (pain lasting at least 3 months)
  • Live in the United States

Exclusion Criteria:

  • None

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Mindfulness curriculum

Participants in this condition receive two mindfulness messages per day at random times as part of a curriculum based on the ACT+MBRP treatment manual.

experimental: Random mindfulness messages

Participants in this condition receive four random mindfulness messages per day at random times from the complete bank of mindfulness messages developed based on the Monitoring and Acceptance Theory of mindfulness.

Interventions

Mindfulness text messages

Over 200 text messages based on concepts from Acceptance and Commitment Therapy (ACT) and Mindfulness-Based Relapse Prevention (MBRP) were developed and are sent to participants each day for 6 weeks. The messages are intended to increase awareness of triggers and "automatic" reactions to triggering experiences, and to consider alternative responses to these experiences.

Primary outcome measure

  • Engagement with mindfulness text messages [ Time Frame: Measured daily for six weeks ]
  • Intervention acceptability [ Time Frame: From baseline to 12-week (i.e., 3-month) follow-up ]
  • Intervention feasibility [ Time Frame: From baseline to 12-week (i.e., 3-month) follow-up ]

Central Contacts and Locations

Central contacts

Locations

University of New Mexico

Recruiting

Albuquerque, New Mexico, United States, 87131

Contacts

More Information

Sponsor

University of New Mexico

Last update posted

Jul 17, 2026

Last verified

Jul, 2026

Keywords

  • text message
  • medications for opioid use disorder
  • mHealth
  • mindfulness
  • medication adherence

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of New Mexico on 2026-07-17.