Recruiting

Clinical Decision Support

Sponsor:

Children's Hospital Medical Center, Cincinnati

Code:

NCT07718464

Conditions

Acute Kidney Injury

Renal Replacement Therapy

Pediatric Intensive Care Unit

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Furosemide Stress Test Clinical Decision Support Tool

Study Details

Brief summary:

The goal of this study is to learn whether adding a clinical decision support tool to the electronic medical record helps clinicians use the furosemide stress test in critically ill children at high risk for severe acute kidney injury (AKI). The main question it aims to answer is: Does implementing the decision support tool reduce fluid overload and help predict which children will receive dialysis?

Researchers will identify children admitted to the pediatric intensive care unit who are at high risk for AKI using risk stratification and biomarker testing, then compare outcomes in the two years after the tool is introduced with the two years before.

Conditions

Acute Kidney Injury

Renal Replacement Therapy

Pediatric Intensive Care Unit

Study ID

NCT07718464

Start date

May 27, 2026

Status verified date

Jul, 2026

Completion date

Jun, 2028

Anticipated

Primary completion date

May, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Admitted to the pediatric intensive care unit (PICU)
  • Renal Angina Index (RAI) greater than or equal to 8 (RAI+)
  • Urine NGAL greater than or equal to 150 ng/mL (NGAL+)

Exclusion Criteria:

  • Receipt of renal replacement therapy prior to PICU admission

Study Design

Enrollment

120 participants

Anticipated

Interventions and Outcome Measures

Arms

Post-Implementation Cohort

All patients with RAI greater than or equal to 8 (RAI+) and NGAL greater than or equal to 150 ng/mL (NGAL+) in the two years after the clinical decision support tool is implemented. These patients will be compared to the cohort of patients with RAI greater than or equal to 8 and NGAL greater than or equal to 150 ng/mL in the two years before the clinical decision support (CDS) tool is implemented.

Interventions

Furosemide Stress Test Clinical Decision Support Tool

The CDS strategy will be developed with key stakeholders in the Cincinnati Children's PICU, leveraging existing infrastructure and workflows. This CDS intervention will then be implemented as part of routine care in the PICU.

Primary outcome measure

  • Change in Day 7 Fluid Accumulation [ Time Frame: 2 years ]

Central Contacts and Locations

Locations

Cincinnati Children's Hospital Medical Center

Recruiting

Cincinnati, Ohio, United States, 45229

Contacts

Natalja L Stanski, MD, MS

513-636-4334natalja.stanski@cchmc.org

Principal Investigator:

Natalja L Stanski, MD, MS

More Information

Sponsor

Children's Hospital Medical Center, Cincinnati

Last update posted

Jul 22, 2026

Last verified

Jul, 2026

Keywords

  • NGAL
  • Renal Angina Index
  • Furosemide Stress Test

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Children's Hospital Medical Center, Cincinnati on 2026-07-22.