Recruiting

Ray Tracing vs. Wavefront

Sponsor:

Stanford University

Code:

NCT07721714

Conditions

Myopia

Astigmatism

Eligibility Criteria

Sex: All

Age: 22 - 59

Healthy Volunteers: Not accepted

Interventions

Ray tracing guided LASIK surgery

Study Details

Brief summary:

Participants will undergo LASIK surgery in one eye using ray tracing guided technology in one eye and LASIK surgery in the other eye using wavefront guided technology. We are comparing outcomes between the two technologies as measured by self reported quality of vision and quality of life outcomes using validated questionnaires before and after surgery. We will also be comparing outcomes between the two technologies including measurement of low contrast visual acuity,and best spectacle corrected visual acuity.

Conditions

Myopia

Astigmatism

Study ID

NCT07721714

Start date

Aug 5, 2026

Status verified date

Aug, 2026

Completion date

Jul 31, 2029

Anticipated

Primary completion date

Dec 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 22 - 59

Healthy Volunteers: Not accepted

Inclusion Criteria:

Subjects age 22 and older with healthy eyes. Nearsightedness between -1.00 diopters and -8.00 diopters.

Subjects with less than or equal to 3.00 diopters of astigmatism.

Exclusion Criteria:

Subjects under the age of 22. Subjects with excessively thin corneas. Subjects with topographic evidence of keratoconus. Subjects with ectactic eye disorders. Subjects with autoimmune diseases. Subjects who are pregnant or nursing. Subjects must have similar levels of nearsightedness in each eye. They can not be more than 1.5 diopter of difference between eyes.

Subjects with more than 3.00 diopters of astigmatism Subjects must have similar levels of astigmatism in each eye. They can not have more than 0.75 diopters of difference between eyes.

Study Design

Enrollment

62 participants

Anticipated

Allocation

Randomized

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Ray tracing guided LASIK surgery

LASIK

active comparator: SMILE surgery

SMILE

Interventions

Ray tracing guided LASIK surgery

LASIK

Primary outcome measure

  • Change in corrected distance visual acuity [ Time Frame: Three months ]

Central Contacts and Locations

Central contacts

Edward E Manche, MD

1-650-498-7020edward.manche@stanford.edu

Locations

Byers Eye Institute

Recruiting

Palo Alto, California, United States, 94303

Contacts

Edward Manche E Manche, MD

650-498-7020cornea@stanford.edu

Principal Investigator:

Edward E Manche, MD

More Information

Sponsor

Stanford University

Last update posted

Aug 26, 2026

Last verified

Aug, 2026

Keywords

  • Ray-tracing
  • LASIK
  • SMILE

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Stanford University on 2026-08-26.