Recruiting

Deep Brain Stimulation

Sponsor:

University of Alabama at Birmingham

Code:

NCT07725315

Conditions

Deep Brain Stimulation

PARKINSON DISEASE (Disorder)

Eligibility Criteria

Sex: All

Age: 30 - 70+

Healthy Volunteers: Not accepted

Interventions

DBS as part of standard of care

Study Details

Brief summary:

The purpose of this pilot study is to assess changes in thinking and movement after deep brain stimulator implantation. The study will also examine whether these changes are related to the risk of falls.

Conditions

Deep Brain Stimulation

PARKINSON DISEASE (Disorder)

Study ID

NCT07725315

Start date

Aug 1, 2026

Status verified date

Oct, 2026

Completion date

Nov 1, 2027

Anticipated

Primary completion date

Nov 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 30 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age between 30-80, patient has elected to undergo DBS surgery as part of routine care, cleared for deep brain stimulation surgery as part of routine care by the movement disorders committee. Refractory motor symptoms such as dyskinesias, wearing off, and/or motor fluctuations, causing significant disability, despite reasonable attempts at medical management, as determined by the consensus DBS committee, able to walk, Patient is available for follow-up over the length of the study

Exclusion Criteria: Patient's insurance will not cover the costs of surgery with investigational devices, Medical contraindications such as current uncontrolled hypertension, heart disease, coagulopathy, or other conditions contraindicating DBS surgery or stimulation, self-report of lack of clear levodopa response, requires a walker or wheelchair for mobility

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Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: DBS for standard of care

Individuals who undergo DBS surgery as part of standard of care will be observed prior to and after DBS surgery and data at these timepoints associated with indicine falls.

Interventions

DBS as part of standard of care

Individuals with Parkinson's Disease will be selected to undergo DBS as part of standard of care. Those individuals will be assessed prior to and 3 months after.

Primary outcome measure

  • Self-Reported Falls [ Time Frame: From enrollment to end of study will be 4-5 months ]

Central Contacts and Locations

Central contacts

Christopher Hurt, PhD

2059345817cphurt@uab.edu

Locations

UAB WHARF at Lakeshore

Recruiting

Homewood, Alabama, United States, 35294

Contacts

Alexandra Evancho, PhD

(205) 975-5229amelgin@uab.edu

More Information

Sponsor

University of Alabama at Birmingham

Last update posted

Oct 26, 2026

Last verified

Oct, 2026

Keywords

  • DBS, Parkinson's disease, Falls

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-27. This information was provided to ClinicalTrials.gov by University of Alabama at Birmingham on 2026-10-26. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.