Recruiting

LLM-generated SIC

Sponsor:

Dana-Farber Cancer Institute

Code:

NCT07735442

Conditions

Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

LLM-generated SIC summary email to clinical teams

Study Details

Brief summary:

This is a pragmatic, prospective, randomized clinical trial to test the effectiveness of large language model (LLM)-generated serious illness conversation (SIC) summaries delivered to patients' inpatient and outpatient clinicians at the time of hospital admission on the primary outcome of days in the hospital in the next 90 days.

Conditions

Cancer

Study ID

NCT07735442

Start date

Aug 4, 2026

Status verified date

Aug, 2026

Completion date

Jun 30, 2028

Anticipated

Primary completion date

Jun 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • DFCI Patients, defined as patients who have a DFCI medical record number.
  • Admitted to an inpatient solid tumor medical oncology service at BWH (including beds that are considered to be DFCI beds within BWH)
  • Age ≥ 18 years
  • Mortality prediction ≥ 25%
  • Admitted on a Sunday after 4pm through Friday at 4pm. These time restrictions are necessary for the workflow of this pragmatic pilot trial, as the intervention requires a staff member to send intervention emails during the work week but within <= approximately 18 hours of admission. Accordingly, we will not enroll patients during holiday time periods (e.g., for a Monday holiday, enrollment would start on Monday at 4pm instead of Sunday at 4pm) or on days where staff absences (e.g., illness) preclude enrollment.

Exclusion Criteria:

• Patients with elective inpatient admissions (typically for planned administration of chemotherapy or other treatments)

Study Design

Enrollment

600 participants

Anticipated

Allocation

Randomized

Intervention Model

Single group

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Arm 1: Intervention Arm

An email is sent to patients' inpatient and outpatient clinical teams containing an LLM-generated summary of prior SIC documentation, prompting clinicians to review and discuss care preferences with the patient and align care with patient goals.

no intervention: Arm 2: Control Arm

Patients receive standard of care; SICs may be initiated by patients or clinicians as usual.

Interventions

LLM-generated SIC summary email to clinical teams

An email containing a summary of prior serious illness conversations, generated by a large language model, is sent to the patient's clinical teams at admission, prompting review and discussion of care preferences.

Primary outcome measure

  • Number of Days in the Hospital [ Time Frame: 90 days after randomization ]

Central Contacts and Locations

Central contacts

Alexi A Wright, MD, MPH

6176322334alexi_wright@dfci.harvard.edu

Charlotta J Lindvall, MD, PhD

6175823491charlotta_lindvall@dfci.harvard.edu

Locations

Brigham and Women's Hospital

Recruiting

Boston, Massachusetts, United States, 02214

Contacts

Alexi A Wright, MD.MPH

617-632-2334alexi_wright@dfci.harvard.edu

Charlotta J Lindvall, MD PhD

6175823401charlotta_lindvall@dfci.harvard.edu

Principal Investigator:

Alexi A Wright, MD, MPH

Dana Farber Cancer Institute

Recruiting

Boston, Massachusetts, United States, 02215

Contacts

Alexi A Wright, MD. MPH

617-632-2334Alexi_Wright@dfci.harvard.edu

Alexi A Wright, MD, MPH

6176322334Alexi_Wright@dfci.harvard.edu

Principal Investigator:

Alexi A Wright, MD, MPH

More Information

Sponsor

Dana-Farber Cancer Institute

Last update posted

Aug 26, 2026

Last verified

Aug, 2026

Keywords

  • Cancer (Solid Tumor)

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Dana-Farber Cancer Institute on 2026-08-26.