Recruiting

TB Screening

Sponsor:

Columbia University

Code:

NCT07737275

Conditions

Tuberculosis (TB)

Tuberculosis Infection, Latent

HIV (Human Immunodeficiency Virus)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Mobile chest radiography for tuberculosis screening

Study Details

Brief summary:

SPOT-TB (Screening with Portable X-rays for rapid recOgniTion of TB) is a prospective study evaluating a community-based tuberculosis (TB) screening strategy for migrant populations in New York City. The screening intervention integrates mobile ultra-portable digital chest radiography with artificial intelligence-assisted image interpretation, tuberculosis symptom assessment, latent tuberculosis infection testing, and HIV testing. Participants with concerning screening findings are referred for appropriate clinical evaluation. The study will evaluate the feasibility, acceptability, and effectiveness of this integrated screening strategy for improving early identification of active pulmonary tuberculosis and linkage to care in community settings.

Conditions

Tuberculosis (TB)

Tuberculosis Infection, Latent

HIV (Human Immunodeficiency Virus)

Study ID

NCT07737275

Start date

Aug 25, 2026

Status verified date

Sep, 2026

Completion date

May 25, 2028

Anticipated

Primary completion date

May 25, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adult persons 18 years or older
  • Self-identifying as migrants to the US
  • Self-reporting migration within the 24 months

Exclusion Criteria:

  • Lack capacity for informed consent
  • Unable to perform translation/study materials not available in appropriate language
  • Unwilling to participate
  • Prisoner
  • Pregnancy

Study Design

Enrollment

1000 participants

Anticipated

Intervention Model

Single group

Primary purpose

Screening

Interventions and Outcome Measures

Arms

experimental: SPOT-TB Screening Intervention

Participants undergo the SPOT-TB screening strategy, which includes symptom screening, chest radiography interpreted using AI software, HIV testing, and collection of sputum for confirmatory microbiologic testing when indicated.

Interventions

Mobile chest radiography for tuberculosis screening

The diagnostic screening includes a digital chest x-ray (includes AI software to interpret x-rays), optional lung ultrasound, oral swab for HIV testing, and a blood draw for TB testing.

Primary outcome measure

  • Completion of Appropriate Clinical Referrals [ Time Frame: Up to 12 weeks post-visit ]

Central Contacts and Locations

Central contacts

Allison Wolf, MPH

212-342-44'1aw2565@cumc.columbia.edu

Locations

African Services Committee

Recruiting

New York, New York, United States, 10027

Contacts

Allison Wolf, MPH

425-408-2122aw2565@cumc.columbia.edu

Max O'Donnell, MD

6465736650mo2130@cumc.columbia.edu

Principal Investigator:

Max O'Donnell, MD

More Information

Sponsor

Columbia University

Last update posted

Oct 2, 2026

Last verified

Sep, 2026

Keywords

  • Tuberculosis
  • Mobile Screening
  • Chest x-ray
  • HIV

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-03. This information was provided to ClinicalTrials.gov by Columbia University on 2026-10-02. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.