Recruiting

Resistance Training & Cardio

Sponsor:

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Code:

NCT07739563

Conditions

Cancer

Breast Cancer

Eligibility Criteria

Sex: Female

Age: 20 - 70+

Healthy Volunteers: Not accepted

Interventions

Resistance Training with Cardio

Resistance Training with Conditioning

Study Details

Brief summary:

In this study, the investigators hypothesize that observed intense resistance training with conditioning elicits similar changes in body composition, muscle mass, and blood pressure as that with cardiovascular training (or cardio) for women treated with breast cancer.

Conditions

Cancer

Breast Cancer

Study ID

NCT07739563

Start date

Jul 27, 2026

Status verified date

Aug, 2026

Completion date

Jul, 2027

Anticipated

Primary completion date

Apr, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 20 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Age 20-89 years
2. Women prescribed exercise as a SOC
3. Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast
4. Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed.
5. Women with > 3 months of resistance training experience under expert guidance by a CSCS
6. Must be able to read and understand English and consent for themselves.

Exclusion Criteria:

1. Any current treatment with cytotoxic chemotherapy for breast cancer
2. Inability to safely engage in group sessions of resistance training as deemed by study PI
3. Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by PI to be unsafe to engage in resistance training
4. Beta blocker or GLP-1 inhibitor medications
5. Pregnant women
6. Males

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Cardio Training

experimental: Conditioning Training

Interventions

Resistance Training with Cardio

Participants in this arm will engage in a supervised exercise regimen three times per week, for approximately 2 months (8 weeks). The regimen combines two days of hypertrophy-focused resistance training with a third day dedicated to steady-state cardiovascular exercise. The cardio day will utilize ergometer-based exercises (rowing ergometer, Assault Air Bike) and unweighted sled pushes, with each activity lasting 10 minutes continuously. The overall program aims to improve cardiorespiratory fitness and body composition in breast cancer survivors, under the guidance of Certified Strength and Conditioning Specialists (CSCS).

Resistance Training with Conditioning

Participants in this arm will engage in a supervised exercise regimen three times per week, for approximately 2 months (8 weeks). The regimen combines two days of hypertrophy-focused resistance training with a third day dedicated to high-intensity conditioning. The conditioning day involves a circuit format of 6 total exercises, completed for 8 repetitions each across 8 sets, with limited rest periods (10 seconds or less) between exercises and sets. Exercise selection is total-body focused, alternating between upper and lower body movements. The program aims to improve muscular conditioning and body composition in breast cancer survivors, under the guidance of Certified Strength and Conditioning Specialists (CSCS).

Primary outcome measure

  • Change in Muscle Mass [ Time Frame: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months). ]
  • Change in Fat Mass [ Time Frame: Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months). ]

Central Contacts and Locations

Central contacts

Clinical Trials Contact

412-330-6151ctgov@ahn.org

Locations

AHN Allegheny General Hospital

Recruiting

Pittsburgh, Pennsylvania, United States, 15212

Contacts

Clinical Trials Contact

412-330-6151ctgov@ahn.org

More Information

Sponsor

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Last update posted

Aug 17, 2026

Last verified

Aug, 2026

Keywords

  • Exercise

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) on 2026-08-17.