Recruiting

Observational Study

Sponsor:

McGill University Health Centre/Research Institute of the McGill University Health Centre

Code:

NCT07739784

Conditions

Glaucoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

No Interventions

Study Details

Brief summary:

The goal of this observational study is to learn whether personality traits are related to eye side effects from glaucoma medications in adults who currently use or previously used these medications.

The main questions this study aims to answer are:

Are certain personality traits associated with the occurrence or severity of eye side effects from glaucoma medications? Do personality traits differ between people who experience these side effects and those who do not?

Participants will complete a questionnaire that measures five personality traits: openness, conscientiousness, extraversion, agreeableness, and neuroticism. They will also provide basic demographic information. The researchers will review participants' medical records to collect information about their glaucoma medications and any related eye side effects, including the type and frequency of side effects and whether treatment was changed because of them.

Participation involves one session lasting approximately 30 minutes. Questionnaires may be completed securely online or in person at the clinic. The study will include approximately 352 adults. No treatment will be assigned or changed as part of this study.

Conditions

Glaucoma

Study ID

NCT07739784

Start date

Feb 25, 2026

Status verified date

Jul, 2026

Completion date

Aug 1, 2027

Anticipated

Primary completion date

Jul 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 years or older.
  • Diagnosis of glaucoma.
  • Current or previous treatment with one or more glaucoma medications.
  • Able to provide informed consent.
  • Able to complete the study questionnaires in English or French.

Exclusion Criteria:

  • Uncontrolled anxiety or depression that was present before glaucoma medication treatment began.
  • Unable to provide informed consent.
  • Unable to complete the study questionnaires in English or French.

Study Design

Enrollment

352 participants

Anticipated

Interventions and Outcome Measures

Arms

Case

Participants with at least one documented ocular adverse effect from a glaucoma medication that resulted in discontinuation of the medication.

Control

Participants without a documented significant ocular adverse effect resulting in medication discontinuation.

Interventions

No Interventions

There is no intervention

Primary outcome measure

  • Difference in Five-Factor Model neuroticism scores between participants with and without significant ocular adverse reactions [ Time Frame: Assessed once during the single study session, lasting approximately 30 minutes. ]

Central Contacts and Locations

Central contacts

Ana Hernandez, MD

15149341934ana.ramirezhernandez@mail.mcgill.ca

Hady Saheb, MD MPH

514-934-1934hady.saheb@mcgill.ca

Locations

McGill University Health Center

Recruiting

Montreal, Quebec, Canada

Contacts

Ana Hernandez, MD

514-934-1934ana.ramirezhernandez@mail.mcgill.ca

More Information

Sponsor

McGill University Health Centre/Research Institute of the McGill University Health Centre

Last update posted

Jul 31, 2026

Last verified

Jul, 2026

Keywords

  • adverse events
  • Personality traits
  • glaucoma

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-25. This information was provided to ClinicalTrials.gov by McGill University Health Centre/Research Institute of the McGill University Health Centre on 2026-07-31. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.