Recruiting

GLP-1RA

Sponsor:

University of Kansas Medical Center

Code:

NCT07743567

Conditions

Pregnant Individuals

Obesity & Overweight

Gestational Weight Gain

Eligibility Criteria

Sex: Female

Age: 18 - 45

Healthy Volunteers: Accepted

Study Details

Brief summary:

The goal of this observational study is to learn if using GLP-1RA medications for weight loss before pregnancy influences gestational weight gain and pregnancy outcomes. The main aims of the study are to:

  • Compare gestational weight gain between women with preconception GLP-1RA exposure and those without exposure.
  • Compare obstetrical outcomes between women with preconception GLP-1RA exposure and those without exposure.

Researchers will compare pregnant women with a history of GLP-1RA use to pregnant women who have not used a GLP-1RA to compare differences.

Participants will be asked to complete questionnaires at multiple timepoints during and after pregnancy that ask questions about medication history, thoughts and feelings around food, etc.

Conditions

Pregnant Individuals

Obesity & Overweight

Gestational Weight Gain

Study ID

NCT07743567

Start date

Apr 13, 2026

Status verified date

Jul, 2026

Completion date

Apr, 2028

Anticipated

Primary completion date

Apr, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 45

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adult women
  • Less than or equal to 20 weeks gestation at first visit
  • English speaking

Exclusion Criteria:

  • <18 years at time of initial visit
  • Type 2 diabetes
  • History of bariatric surgery
  • Multiple gestation
  • Cannot consent for themselves
  • Cannot read and speak English
  • Incarcerated

Study Design

Enrollment

400 participants

Anticipated

Interventions and Outcome Measures

Arms

GLP-1RA users

Participants with a history of GLP-1RA use.

GLP-1RA nonusers

Participants who have never used a GLP-1RA medication.

Primary outcome measure

  • Gestational weight gain [ Time Frame: From the start of pregnancy to delivery. ]

Central Contacts and Locations

Central contacts

Molly Fain

913-588-5478mfain3@kumc.edu

Locations

University of Kansas Medical Center

Recruiting

Kansas City, Kansas, United States, 66160

Contacts

Molly Fain

913-588-5478mfain3@kumc.edu

Principal Investigator:

Johanna Finkle, MD

More Information

Sponsor

University of Kansas Medical Center

Last update posted

Aug 4, 2026

Last verified

Jul, 2026

Keywords

  • Glucagon-like peptide 1 receptor agonist
  • Pregnancy
  • Gestational weight gain
  • Maternal obesity
  • Pregnancy outcomes
  • Food noise
  • Preconception

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Kansas Medical Center on 2026-08-04.