Recruiting

Observational Study

Sponsor:

Children's National Research Institute

Code:

NCT07746167

Conditions

Healthy Participants

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Accepted

Interventions

No intervention (observational study)

Study Details

Brief summary:

This a single site, observational study that will examine how the pupil responds to neurostimulation under different conditions in healthy adults. The objective is to measure pupillary dilation reflex (PRD) in response to increasing neurostimulation intensities using the AlgometRx device.

Conditions

Healthy Participants

Study ID

NCT07746167

Start date

Apr 29, 2026

Status verified date

Jul, 2026

Completion date

Jun, 2027

Anticipated

Primary completion date

Apr, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 60

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age 18-60 years.
  • In good general health (self-reported).
  • Able and willing to provide written informed consent.

Exclusion Criteria:

  • Eye pathology that prevents accurate pupillometry.
  • Pregnancy (Self-Report)
  • Diagnosis of autoimmune disorders.
  • Diagnosis of any neuropathic disorder
  • Inability to complete questionnaires.

Study Design

Enrollment

60 participants

Anticipated

Interventions and Outcome Measures

Arms

Healthy Volunteers

Interventions

No intervention (observational study)

No intervention

Primary outcome measure

  • Pupillary Dilation Amplitude in Response to Increasing Neurostimulation Intensity Measured by AlgometRx Infrared Pupillometer [ Time Frame: Day 1 ]

Central Contacts and Locations

Locations

Children's National Hospital

Recruiting

Washington D.C., District of Columbia, United States, 20010

Contacts

Julia Finkel, MD

202-476-4867jfinkel@childrensnational.org

More Information

Sponsor

Children's National Research Institute

Last update posted

Aug 4, 2026

Last verified

Jul, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Children's National Research Institute on 2026-08-04.